diff --git a/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.integration.test.ts b/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.integration.test.ts
index 46ae9740c078..64742a87903b 100644
--- a/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.integration.test.ts
+++ b/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.integration.test.ts
@@ -13,6 +13,7 @@ const SELECTORS = {
   card: '.dx-cardview-card',
   cardCheckbox: '.dx-checkbox-container',
   selectAllButton: '[aria-label="Select all"]',
+  clearSelectionButton: '[aria-label="Clear selection"]',
 };
 
 const setup = (options: GridCoreOptions = {}): CardView => {
@@ -31,6 +32,8 @@ const getCardCheckboxes = (): NodeListOf<Element> => document.querySelectorAll(S
 
 const getSelectAllButton = (): Element | null => document.querySelector(SELECTORS.selectAllButton);
 
+const getClearSelectionButton = (): Element | null => document.querySelector(SELECTORS.clearSelectionButton);
+
 const checkError = (): void => expect(throwError).toHaveBeenCalledWith('E1042', 'CardView');
 
 jest.mock('@ts/grids/new/grid_core/options_validation/utils', () => ({
@@ -175,6 +178,30 @@ describe('when keyExpr is missing', () => {
   });
 });
 
+describe('clear selection toolbar button', () => {
+  it('should clear selection after runtime selectedCardKeys option update', () => {
+    const cardView = setup({
+      keyExpr: 'id',
+      dataSource: [{ id: 1 }, { id: 2 }],
+      selection: {
+        mode: 'multiple',
+      },
+      selectedCardKeys: [],
+    });
+
+    expect(cardView.getSelectedCardKeys()).toEqual([]);
+
+    cardView.option('selectedCardKeys', [2]);
+
+    expect(cardView.getSelectedCardKeys()).toEqual([2]);
+
+    const clearSelectionButton = getClearSelectionButton();
+    clearSelectionButton?.dispatchEvent(new MouseEvent('click'));
+
+    expect(cardView.getSelectedCardKeys()).toEqual([]);
+  });
+});
+
 describe('selectAll with filters', () => {
   it('should select only cards matching filterValue', () => {
     const cardView = setup({
diff --git a/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.test.ts b/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.test.ts
index 5f47fca4b12d..042eeff4b9cf 100644
--- a/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.test.ts
+++ b/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.test.ts
@@ -42,6 +42,29 @@ describe('SelectionController', () => {
       selectionController.selectCards([1]);
       expect(itemsController.items).toMatchSnapshot();
     });
+
+    it('should only be called once when selectedCardKeys are updated', () => {
+      const {
+        selectionController,
+        optionsController,
+      } = setup({
+        keyExpr: 'id',
+        dataSource: [{ id: 1, value: 'test' }, { id: 2, value: 'test2' }],
+        selection: {
+          mode: 'multiple',
+        },
+      });
+
+      const selectCardsSpy = jest.spyOn(selectionController, 'selectCards');
+
+      optionsController.option('selectedCardKeys', [1]);
+
+      expect(selectCardsSpy).toHaveBeenCalledTimes(1);
+
+      optionsController.option('selectedCardKeys', []);
+
+      expect(selectCardsSpy).toHaveBeenCalledTimes(2);
+    });
   });
 
   describe('deselectCards', () => {
diff --git a/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.ts b/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.ts
index aeb452890f66..98ef90b6d003 100644
--- a/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.ts
+++ b/packages/devextreme/js/__internal/grids/new/grid_core/selection/controller.ts
@@ -154,14 +154,15 @@ export class SelectionController {
       Need to get rid of `selectionHelper.peek()` inside of selectCards()
       and pass selectionHelper from here
       */
-      // eslint-disable-next-line @typescript-eslint/no-unused-expressions
-      this.selectionHelper.value;
-
+      const selectionHelper = this.selectionHelper.value;
       const isLoaded = this.dataController.isLoaded.value;
       if (isLoaded) {
-        const selectedCardKeys = this.selectedCardKeys.peek();
+        const keys = this.selectedCardKeys.value;
+        const hasExactSelectedItems = selectionHelper?.hasExactSelectedItems(keys);
 
-        this.selectCards(selectedCardKeys);
+        if (!hasExactSelectedItems) {
+          this.selectCards(keys);
+        }
       }
     });
 
diff --git a/packages/devextreme/js/__internal/ui/selection/selection.ts b/packages/devextreme/js/__internal/ui/selection/selection.ts
index cf5ba98cbb3f..20a62ae1a6a2 100644
--- a/packages/devextreme/js/__internal/ui/selection/selection.ts
+++ b/packages/devextreme/js/__internal/ui/selection/selection.ts
@@ -402,4 +402,15 @@ export default class Selection<
   loadSelectedItemsWithFilter(): DeferredObj<unknown> {
     return this._selectionStrategy.loadSelectedItemsWithFilter();
   }
+
+  hasExactSelectedItems(keys: TKey[]): boolean {
+    const { selectedItems, keyOf } = this.options;
+    if (keys.length === selectedItems.length) {
+      return keys.every((key) => selectedItems.some((item) => {
+        const isKeysEqual = this._selectionStrategy.equalKeys(keyOf(item), key);
+        return isKeysEqual;
+      }));
+    }
+    return false;
+  }
 }