@@ -46,7 +46,7 @@ class Config:
4646 SPC_ANALYSIS_DIR = Path ("/nemo/stp/hts/working/Joe_Tuersley/code/spc-cosine-analysis/analysis/20251122_HaCaT_gsk_all_no_CRISPR_no_HTC_V1_no_CCA_V1_ResNet18/spc_analysis_20251124_174723" )
4747
4848 # CellProfiler Analysis Directory
49- CP_ANALYSIS_DIR = Path ("/nemo/project/proj-prosperity/hts/raw/projects/20251111_gsk_prosperity_all_datasets/cellprofiler/processed_data/20251120_124820_from_well_results " )
49+ CP_ANALYSIS_DIR = Path ("/nemo/project/proj-prosperity/hts/raw/projects/20251111_gsk_prosperity_all_datasets/cellprofiler/processed_data/20251125_152508_results " )
5050
5151 THUMBNAIL_DIRS = [
5252 # CRISPR genome
@@ -65,7 +65,7 @@ class Config:
6565 SPC_ANALYSIS_DIR = Path ("/Volumes/hts/working/Joe_Tuersley/code/spc-cosine-analysis/analysis/20251122_HaCaT_gsk_all_no_CRISPR_no_HTC_V1_no_CCA_V1_ResNet18/spc_analysis_20251124_174723" )
6666
6767 # CellProfiler Analysis Directory
68- CP_ANALYSIS_DIR = Path ("/Volumes/proj-prosperity/hts/raw/projects/20251111_gsk_prosperity_all_datasets/cellprofiler/processed_data/20251120_124820_from_well_results " )
68+ CP_ANALYSIS_DIR = Path ("/Volumes/proj-prosperity/hts/raw/projects/20251111_gsk_prosperity_all_datasets/cellprofiler/processed_data/20251125_152508_results " )
6969
7070 THUMBNAIL_DIRS = [
7171 # CRISPR genome
@@ -205,52 +205,51 @@ class Config:
205205
206206 # --- SPC HOVER COLUMNS ---
207207 SPC_HOVER_COLUMNS = [
208- 'plate' , 'well' , 'treatment' , 'SMILES' ,
209- 'compound_name' , 'compound_uM' , 'PP_ID' , 'PP_ID_uM' , 'library' ,
210- 'moa_first' , 'moa_truncated_10' , 'moa_compound_uM' ,
211- 'annotated_target_description_truncated_10' , 'target_description_truncated_10' ,
212- 'chemical_description' , 'manual_annotation' , 'compound_type' ,
213- 'landmark_label' , 'is_landmark' , 'valid_for_phenotypic_makeup' ,
214- 'cosine_distance_from_dmso' , 'mad_cosine' ,
215- # 1st Landmark
216- 'closest_landmark_moa_first' , 'closest_landmark_PP_ID' , 'closest_landmark_PP_ID_uM' ,
217- 'closest_landmark_distance' , 'closest_landmark_annotated_target_description_truncated_10' ,
218- 'closest_landmark_manual_annotation' , 'closest_landmark_SMILES' ,
219- # 2nd Landmark - ADDED target description
220- 'second_closest_landmark_moa_first' , 'second_closest_landmark_PP_ID_uM' ,
221- 'second_closest_landmark_distance' ,
222- 'second_closest_landmark_annotated_target_description_truncated_10' ,
223- 'second_closest_landmark_manual_annotation' ,
224- # 3rd Landmark - ADDED target description
225- 'third_closest_landmark_moa_first' , 'third_closest_landmark_PP_ID_uM' ,
226- 'third_closest_landmark_distance' ,
227- 'third_closest_landmark_annotated_target_description_truncated_10' ,
228- 'third_closest_landmark_manual_annotation' ,
229- 'gene_description' ,
208+ 'plate' , 'well' , 'treatment' , 'SMILES' ,
209+ 'compound_name' , 'compound_uM' , 'PP_ID' , 'PP_ID_uM' , 'library' ,
210+ 'moa_first' , 'moa_truncated_10' , 'moa_compound_uM' ,
211+ 'annotated_target_description_truncated_10' , 'target_description_truncated_10' ,
212+ 'chemical_description' , 'compound_type' , 'manual_annotation' , # compound_type FIRST for SPC!
213+ 'is_landmark' , # REMOVED landmark_label and valid_for_phenotypic_makeup
214+ 'cosine_distance_from_dmso' , 'mad_cosine' ,
215+ # 1st Landmark
216+ 'closest_landmark_moa_first' , 'closest_landmark_PP_ID' , 'closest_landmark_PP_ID_uM' ,
217+ 'closest_landmark_distance' , 'closest_landmark_annotated_target_description_truncated_10' ,
218+ 'closest_landmark_manual_annotation' , 'closest_landmark_SMILES' ,
219+ # 2nd Landmark
220+ 'second_closest_landmark_moa_first' , 'second_closest_landmark_PP_ID_uM' ,
221+ 'second_closest_landmark_distance' ,
222+ 'second_closest_landmark_annotated_target_description_truncated_10' ,
223+ 'second_closest_landmark_manual_annotation' ,
224+ # 3rd Landmark
225+ 'third_closest_landmark_moa_first' , 'third_closest_landmark_PP_ID_uM' ,
226+ 'third_closest_landmark_distance' ,
227+ 'third_closest_landmark_annotated_target_description_truncated_10' ,
228+ 'third_closest_landmark_manual_annotation' ,
230229 ]
231230
232231 CP_HOVER_COLUMNS = [
233- 'plate' , 'well' , 'treatment' , 'SMILES' ,
234- 'compound_name' , 'compound_uM' , 'PP_ID' , 'PP_ID_uM' , 'library' ,
235- 'moa_first' , 'moa_truncated_10' , 'moa_compound_uM' ,
236- 'target_description_truncated_10' ,
237- 'chemical_description' , 'manual_annotation' , 'compound_type' ,
238- 'is_landmark' , 'valid_for_phenotypic_makeup ' ,
239- 'cosine_distance_from_dmso' , 'mad_cosine' ,
240- # 1st Landmark
241- 'closest_landmark_moa_first' , 'closest_landmark_PP_ID' , 'closest_landmark_PP_ID_uM' ,
242- 'closest_landmark_distance' , 'closest_landmark_annotated_target_description_truncated_10' ,
243- 'closest_landmark_manual_annotation' , 'closest_landmark_SMILES' ,
244- # 2nd Landmark - ADDED target description
245- 'second_closest_landmark_moa_first' , 'second_closest_landmark_PP_ID_uM' ,
246- 'second_closest_landmark_distance' ,
247- 'second_closest_landmark_annotated_target_description_truncated_10' ,
248- 'second_closest_landmark_manual_annotation' ,
249- # 3rd Landmark - ADDED target description
250- 'third_closest_landmark_moa_first' , 'third_closest_landmark_PP_ID_uM' ,
251- 'third_closest_landmark_distance' ,
252- 'third_closest_landmark_annotated_target_description_truncated_10' ,
253- 'third_closest_landmark_manual_annotation' ,
232+ 'plate' , 'well' , 'treatment' , 'SMILES' ,
233+ 'compound_name' , 'compound_uM' , 'PP_ID' , 'PP_ID_uM' , 'library' ,
234+ 'moa_first' , 'moa_truncated_10' , 'moa_compound_uM' ,
235+ 'annotated_target_description_truncated_10' , 'target_description_truncated_10' ,
236+ 'chemical_description' , 'manual_annotation' , 'compound_type' , # manual_annotation FIRST for CP!
237+ 'is_landmark' ,
238+ 'cosine_distance_from_dmso' , 'mad_cosine' ,
239+ # 1st Landmark
240+ 'closest_landmark_moa_first' , 'closest_landmark_PP_ID' , 'closest_landmark_PP_ID_uM' ,
241+ 'closest_landmark_distance' , 'closest_landmark_annotated_target_description_truncated_10' ,
242+ 'closest_landmark_manual_annotation' , 'closest_landmark_SMILES' ,
243+ # 2nd Landmark
244+ 'second_closest_landmark_moa_first' , 'second_closest_landmark_PP_ID_uM' ,
245+ 'second_closest_landmark_distance' ,
246+ 'second_closest_landmark_annotated_target_description_truncated_10' ,
247+ 'second_closest_landmark_manual_annotation' ,
248+ # 3rd Landmark
249+ 'third_closest_landmark_moa_first' , 'third_closest_landmark_PP_ID_uM' ,
250+ 'third_closest_landmark_distance' ,
251+ 'third_closest_landmark_annotated_target_description_truncated_10' ,
252+ 'third_closest_landmark_manual_annotation' ,
254253 ]
255254
256255
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