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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<title>Metabolomics Workbench File Validator</title>
<link rel="stylesheet" href="styles/styles.css"/>
</head>
<body class="background">
<div>
<h1><a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/" style="text-decoration:none;color:white;">Metabolomics Workbench File Validator</a></h1>
<p>
Last Updated: 2026-04-12 09:36:44.578654
</p>
</div>
<div>
<h2>Statistics</h2>
<p>
Number of Studies: 50<br>
Number of Analyses: 54<br>
</p>
<h3>Validation Statistics</h3>
<div class="stats__grid">
<div class="stats__grid__item">Status</div>
<div class="stats__grid__item">mwTab</div>
<div class="stats__grid__item">JSON</div>
<a href="https://35.github.io/MoseleyBioinformaticsLab/passing" class="stats__grid__item brightgreen">Passing</a>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item">0</div>
<a href="https://35.github.io/MoseleyBioinformaticsLab/passing" class="stats__grid__item yellow">Warnings Only</a>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item">0</div>
<a href="https://35.github.io/MoseleyBioinformaticsLab/validation_error" class="stats__grid__item orange">Validation Error</a>
<div class="stats__grid__item">22</div>
<div class="stats__grid__item">19</div>
<a href="https://35.github.io/MoseleyBioinformaticsLab/parsing_error" class="stats__grid__item red">Parsing Error</a>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item">0</div>
<a href="https://35.github.io/MoseleyBioinformaticsLab/missing" class="stats__grid__item brightred">Missing</a>
<div class="stats__grid__item">32</div>
<div class="stats__grid__item">35</div>
</div>
<p></p>
<div class="stats__grid">
<div class="stats__grid__item">Validation Error Type</div>
<div class="stats__grid__item">mwTab</div>
<div class="stats__grid__item">JSON</div>
<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/value" class="stats__grid__item orange">Value Error</a>
<div class="stats__grid__item">22</div>
<div class="stats__grid__item">19</div>
<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/consistency" class="stats__grid__item orange">Consistency Error</a>
<div class="stats__grid__item">2</div>
<div class="stats__grid__item">1</div>
<a href="https://MoseleyBioinformaticsLab.github.io/mwFileStatusWebsite/format" class="stats__grid__item orange">Format Error</a>
<div class="stats__grid__item">3</div>
<div class="stats__grid__item">6</div>
</div>
<h3>mwTab vs JSON Comparison Statistics</h3>
<div class="compare__stats__grid">
<div class="stats__grid__item">Status</div>
<div class="stats__grid__item">Count</div>
<div class="stats__grid__item brightgreen">Consistent</div>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item orange">Inconsistent</div>
<div class="stats__grid__item">0</div>
<div class="stats__grid__item lightgrey">Not Checked</div>
<div class="stats__grid__item">54</div>
</div>
</div>
<div>
<h2>File Status</h2>
<div class="grid header">
<input type="checkbox" id="study_grid_item0" class="study_checkbox"/>
<label for="study_grid_item0" href="#ST001385" class="study__grid__item">ST001385: Urine Metabolomics - Icahn School of Medicine at Mount Sinai - Petrick, Lauren</label>
<div class="grid__description" style="height:8em;max-height:8">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Urine Metabolomics</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">To perform an untargeted metabolomics analysis of urine samples, matrix blanks and quality control samples. The metabolomics approach will be performed using both reverse phase (RP) and HILIC chromatography (ZHP) separations coupled to high-resolution mass spectrometry. Samples were received and stored at -80°C until processing. In total, 315 samples had sufficient sample volume for metabolomics analysis.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Icahn School of Medicine at Mount Sinai</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Petrick</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Lauren</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Department of Environmental Medicine and Public Health, Atran Building 3rd floor, 101st St. between Madison and 5th Ave, New York, New York, 10029, USA</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">lauren.petrick@mssm.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">212 241 7351</div>
</div>
</div>
</div>
<div class="grid">
<input type="checkbox" id="analysis_grid_item1" class="analysis_checkbox"/>
<label for="analysis_grid_item1" href="#AN002312" class="analysis__grid__item brightred">AN002312</label>
<div class="grid__description">
<div>
<span>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN002312/mwtab/txt" target="_blank">txt</a>
</div>
<div class="shieldRight brightred">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN002312_txt.log" target="_blank">Missing/Blank</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN002312/mwtab/json" target="_blank">json</a>
</div>
<div class="shieldRight orange">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN002312_json.log" target="_blank">Validation Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN002312/mwtab/comparison" target="_blank">comparison</a>
</div>
<div class="shieldRight lightgrey">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN002312_comparison.log" target="_blank">Not Checked</a>
</div>
</div>
</span>
</div>
<br>
<div class="desc__grid">
<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN002312</div>
</div>
</div>
</div> <br> <div class="grid header">
<input type="checkbox" id="study_grid_item1" class="study_checkbox"/>
<label for="study_grid_item1" href="#ST003104" class="study__grid__item">ST003104: Metabolomics studies on human cardiac samples - University of Sydney - Koay, Yen Chin</label>
<div class="grid__description" style="height:13em;max-height:13">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Metabolomics studies on human cardiac samples</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Targeted metabolomics was performed to measure polar metabolites in both positive and negative ionization mode on left ventricular tissue acquired from pre-mortem healthy donor hearts as classified by formal pathological examination and stored at the Sydney Heart Bank. The minimum number of observations for young (age ≤ 25 years) and old (age ≥ 50 years) cohorts using liquid chromatography-tandem mass spectrometry (LC-MS/MS).</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Sydney</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Medicine and Health</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Koay</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Yen Chin</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Charles Perkin Centre</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">yen.koay@sydney.edu.au</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">+61486275851</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">2</div>
<div class="desc__grid__item">TOTAL_SUBJECTS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">25</div>
<div class="desc__grid__item">NUM_MALES</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">15</div>
<div class="desc__grid__item">NUM_FEMALES</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">10</div>
</div>
</div>
</div>
<div class="grid">
<input type="checkbox" id="analysis_grid_item2" class="analysis_checkbox"/>
<label for="analysis_grid_item2" href="#AN005082" class="analysis__grid__item brightred">AN005082</label>
<div class="grid__description">
<div>
<span>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN005082/mwtab/txt" target="_blank">txt</a>
</div>
<div class="shieldRight brightred">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN005082_txt.log" target="_blank">Missing/Blank</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN005082/mwtab/json" target="_blank">json</a>
</div>
<div class="shieldRight orange">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN005082_json.log" target="_blank">Validation Error</a>
</div>
</div>
<div class="shield">
<div class="shieldLeft grey">
<a href="https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN005082/mwtab/comparison" target="_blank">comparison</a>
</div>
<div class="shieldRight lightgrey">
<a href="https://raw.githubusercontent.com/MoseleyBioinformaticsLab/mwFileStatusWebsite/master/validation_logs/AN005082_comparison.log" target="_blank">Not Checked</a>
</div>
</div>
</span>
</div>
<br>
<div class="desc__grid">
<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN005082</div>
</div>
</div>
</div> <br> <div class="grid header">
<input type="checkbox" id="study_grid_item2" class="study_checkbox"/>
<label for="study_grid_item2" href="#ST003113" class="study__grid__item">ST003113: Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression, investigated with targeted tracing metabolomics analysis in MEF cells using 15N2-glutamine. - San Raffaele University - Stefanoni, Davide</label>
<div class="grid__description" style="height:8em;max-height:8">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Inhibition of Asparagine Synthetase Effectively Retards Polycystic Kidney Disease Progression, investigated with targeted tracing metabolomics analysis in MEF cells using 15N2-glutamine.</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Polycystic Kidney Disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the enzyme asparagine synthetase (ASNS). Here, we used antisense oligonucleotides (ASO) against Asns in orthologous and slowly progressive PKD murine models and show that treatment leads to a drastic reduction of total kidney volume (measured by MRI) and a prominent rescue of renal function in the mouse. Mechanistically, the upregulation of an ATF4-ASNS axis in PKD is driven by the amino acid response (AAR) branch of the integrated stress response (ISR). Metabolic profiling of PKD or control kidneys treated with Asns-ASO or Scr-ASO revealed major changes in the mutants, several of which are rescued by Asns silencing in vivo. Indeed, ASNS drives glutamine-dependent de novo pyrimidine synthesis and proliferation in cystic epithelia. Notably, while several metabolic pathways were completely corrected by Asns-ASO, glycolysis was only partially restored. Accordingly, combining the glycolytic inhibitor 2DG with Asns-ASO further improved efficacy. Our studies identify a new therapeutic target and novel metabolic vulnerabilities in PKD. Of interest, in these tracing studies we could confirm that the pyrimidine biosynthesis pathway is increased and rescued by silencing of Asns.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">San Raffaele University</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Stefanoni</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Davide</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Via Olgettina 58, Milan, Milan, 20132, Italy</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">stefanoni.davide@hsr.it</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">+393337686005</div>
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN005098</div>
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<label for="analysis_grid_item4" href="#AN005099" class="analysis__grid__item brightred">AN005099</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN005099</div>
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<input type="checkbox" id="study_grid_item3" class="study_checkbox"/>
<label for="study_grid_item3" href="#ST003389" class="study__grid__item">ST003389: Disruption of Glucose Homeostasis by Bacterial Infection Orchestrates Host Innate Immunity Through NAD+/NADH Balance - Northwest A&F University - Xu, Lei</label>
<div class="grid__description" style="height:8em;max-height:8">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Disruption of Glucose Homeostasis by Bacterial Infection Orchestrates Host Innate Immunity Through NAD+/NADH Balance</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Metabolic reprogramming is crucial for activating innate immunity in macrophages, and the accumulation of immunometabolites is thought essential for effective defense against infection. The NAD+/NADH redox couple serves as a critical node that integrates metabolic pathways and signaling events, but how this metabolite couple engages macrophage activation remains unclear. Here, we showed that the NAD+/NADH ratio serves as a molecular signal that regulates proinflammatory responses and type I interferon (IFN) responses divergently. Salmonella Typhimurium infection led to a decreased NAD+/NADH ratio by inducing the accumulation of NADH. Further investigation showed that an increased NAD+/NADH ratio correlates to attenuated proinflammatory responses and enhanced type I IFN responses. Conversely, a decreased NAD+/NADH ratio is linked to intensified proinflammatory responses and restrained type I IFN responses. These results showed the NAD+/NADH ratio is an essential cell-intrinsic factor that orchestrates innate immunity, which enhanced our understanding of how metabolites fine-tune innate immunity.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Northwest A&F University</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Xu</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Lei</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Yangling, Xinong Road, Xiyang, 712100, China</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">xulei@nwafu.edu.cn</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">18149321513</div>
</div>
</div>
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN005557</div>
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<input type="checkbox" id="study_grid_item4" class="study_checkbox"/>
<label for="study_grid_item4" href="#ST003687" class="study__grid__item">ST003687: Cross-sectional salivary metabolomics of the Fin-HIT corhort - Ghent University - callemeyn, emile</label>
<div class="grid__description" style="height:10em;max-height:10">
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<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Cross-sectional salivary metabolomics of the Fin-HIT corhort</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">This study is part of a multi-part study, including salivary metabolomics of 4 patient cohorts.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Ghent University</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Department of Translational Physiology, Infectiology and Public Health</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Laboratory of Integrative Metabolomics</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">callemeyn</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">emile</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Salisburylaan 133, 9820 Merelbeke, Belgium</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">emile.callemeyn@ugent.be</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">0499976319</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN006051</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN006148</div>
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<input type="checkbox" id="study_grid_item6" class="study_checkbox"/>
<label for="study_grid_item6" href="#ST003819" class="study__grid__item">ST003819: Polar metabolite profiling of SLC31A1 knockout cells compared to intergenic sgRNA containing cells - Boston Childrens Hospital - Wong, Alan</label>
<div class="grid__description" style="height:9em;max-height:9">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Polar metabolite profiling of SLC31A1 knockout cells compared to intergenic sgRNA containing cells</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">To investigate the effects of SLC31A1 knockout on steady state metabolite levels, SEM (acute lymphoblastic leukaemia cell line) cells containing either a SLC31A1-targeting sgRNA (two different guides, guide #2 or guide #4) or a intergenic -targetting sgRNA (i.e. a control sgRNA, "Intergenic1") and Cas9 were FACS-purified (Fluorescence Activated Cell Sorting) based on SLC31A1 expression. Cells were then cultured in RPMI-1640 containing 10% FBS and penicillin and streptomycin in 6-well plates, and then collected for metabolomics. SLC31A1 knockout cells were found to exhibit profound electron transport chain inhibition, resulting in accumulation of carbamoyl aspartic acid/ureidosuccinic acid, and depletion of aspartate, as well as broad changes in nucleotide mono, di and triphosphate levels.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Boston Childrens Hospital</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Wong</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Alan</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">300 Longwood Avenue</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">alan.wong@childrens.harvard.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">(617) 355-7433</div>
<div class="desc__grid__item">NUM_GROUPS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">4</div>
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<label for="analysis_grid_item8" href="#AN006279" class="analysis__grid__item brightred">AN006279</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN006279</div>
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<label for="study_grid_item7" href="#ST003967" class="study__grid__item">ST003967: Androgen receptors promote oxidative phosphorylation and resistance to palmitate lipotoxicity in estrogen receptor-mutant breast cancer - University of Colorado Denver - Haines, Julie</label>
<div class="grid__description" style="height:8em;max-height:8">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Androgen receptors promote oxidative phosphorylation and resistance to palmitate lipotoxicity in estrogen receptor-mutant breast cancer</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Aromatase inhibitors (AI) are first-line therapy for postmenopausal women with estrogen receptor-expressing (ER+) breast cancer (BC). AI therapy effectively reduces recurrence and extends lifespan for patients with ER+ breast cancer through long term estrogen deprivation (LTED) resulting from inhibition of the enzyme aromatase that converts androgens to estrogens. However, up to 50% of ER+ BC recurs as AI resistant metastatic disease within 10 years of diagnosis. AI resistant BC upregulates androgen receptors (AR) and mitochondrial oxidative phosphorylation (OXPHOS) and requires OXPHOS and fatty acid oxidation (FAO). The liver and lung, common ER+ BC metastatic sites, have high abundance of the saturated fatty acid palmitate (PA). We asked whether AR signaling regulates OXPHOS in the context of LTED. Using mutant ER-expressing MCF7 and T47D BC cell lines with AR antagonism via the anti-androgen enzalutamide and with shRNA knockdown, we demonstrate that AR supports cell growth, OXPHOS, FAO, and resistance to PA lipotoxicity. We identify AR as a positive regulator of the carnitine acyltransferase family enzyme CRAT that promotes OXPHOS capacity. These studies identify AR as pro-tumor in the LTED setting and as a therapeutic target for ER-mutant BC that develops under the selective pressure of AI therapy.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Colorado Denver</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Haines</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Julie</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">12801 E 17th Ave, Room 1303, Aurora, Colorado, 80045, USA</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">julie.haines@cuanschutz.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">3037243339</div>
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<label for="analysis_grid_item9" href="#AN006527" class="analysis__grid__item brightred">AN006527</label>
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<div class="desc__grid__item">ANALYSIS_ID</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN006527</div>
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<label for="study_grid_item8" href="#ST003999" class="study__grid__item">ST003999: Measuring PEMT activity in HCMV infected fibroblasts using 13C-methionine. - University of Arizona - Kline, Ian</label>
<div class="grid__description" style="height:11em;max-height:11">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Measuring PEMT activity in HCMV infected fibroblasts using 13C-methionine.</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">HCMV promotes the levels of PC lipids in infection. The Kennedy pathway is the canonical host pathway for de novo PC lipid synthesis. Host cells encode alternative pathways for PC synthesis such as the Phosphatidylethanolamine N-methyltransferase (PEMT) pathway. Here, we tested if HCMV promotes metabolic activity in the PEMT pathway. We used 13C-methionine to track the metabolism of labeled tracer molecule into the head group of PC lipids thus, measuring PEMT pathway activity. We find that HCMV and uninfected cells exhibit similarly low PEMT metabolic activity and percentage of labeled PCs. Moreover, when cells were engineered to overexpress the host PEMT enzyme, PC labeling via PEMT increased when expression was induced with doxycycline. Overexpressing GFP and feeding labeled molecule resulted in labeling similar to mock and infected labeling percentages, <5%. Thus, PEMT is not an active pathway in the primary human fibroblasts used in our studies and HCMV infection does not increase metabolic activity of PEMT to synthesize PCs.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Arizona</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Immunobiology</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">John G. Purdy, PhD</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Kline</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Ian</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">1657 E Helen St, Tucson, AZ 85721</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">ikline@arizona.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">5209092596</div>
<div class="desc__grid__item">SUBMIT_DATE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">2025-06-09</div>
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<label for="analysis_grid_item10" href="#AN006593" class="analysis__grid__item brightred">AN006593</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN006593</div>
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<label for="study_grid_item9" href="#ST004323" class="study__grid__item">ST004323: Human Hearts intrinsically increase cardiomyocyte mitosis following myocardial infarction - University of Sydney - Hume, Robert</label>
<div class="grid__description" style="height:10em;max-height:10">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Human Hearts intrinsically increase cardiomyocyte mitosis following myocardial infarction</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Background: Myocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to a third of the cardiomyocytes (CMs) within the human heart. Although CMs undergo mitosis during early development, most CMs cease cell cycling soon after birth. In contrast, rodent MI models have shown that CMs increase mitosis in response to ischemia, however this has not been shown in humans. Methods: Using a unique pre-mortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human CM mitosis post-MI. Results: We show that adult human CMs exhibit increased mitosis and cytokinesis in response to ischemia. Conclusions: Future development of therapeutics to enhance this intrinsic mitotic potential could lead to new treatments that reverse heart failure via cardiac regeneration. This uploaded dataset relates to the metabolomics (HILIC and AMIDE) performed on the unique infarcted human heart (5 days post-myocardial infarction) as compared to healthy donor hearts. Infarct samples consisted of non-ischemic right atrium (MI RA, technical replicates), partially ischemic right ventricle (MI RV, technical replicates), ischemic left ventricle (MI LV, technical replicates) and non-ischemic left ventricle donor tissue (Donor LV, biological replicates).</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Sydney</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Charles Perkins Centre</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Hume</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Robert</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">John Hopkins Dr</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">robert.hume@sydney.edu.au</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">0434848772</div>
<div class="desc__grid__item">DISEASE_ASSOCIATION</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Donor left ventricle or infarct (MI) left ventricle, right ventricle or right atrium</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN007203</div>
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<input type="checkbox" id="study_grid_item10" class="study_checkbox"/>
<label for="study_grid_item10" href="#ST004372" class="study__grid__item">ST004372: Assessing the effect of Aspirin treatment on Arachidonic acid levels in PIK3CA mutant and wild-type isogenic cells - The Institute of Cancer Research London - Poulogiannis, George</label>
<div class="grid__description" style="height:10em;max-height:10">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Assessing the effect of Aspirin treatment on Arachidonic acid levels in PIK3CA mutant and wild-type isogenic cells</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">It has been established that PIK3CA-mutant cancers exhibit elevated arachidonic acid levels compared with PIK3CA wild-type tumours, driven in part by activation of cPLA2 downstream of hyperactivated PI3K signalling. Epidemiological and experimental studies have further suggested a strong anti-cancer effect of aspirin in PIK3CA-mutant tumours, although the underlying mechanism and its therapeutic relevance have remained unclear. In the present work, we demonstrate that aspirin suppresses prostaglandin synthesis through a COX-independent mechanism, specifically via acetylation-mediated inhibition of cPLA2, leading to reduced arachidonic acid availability in PIK3CA-mutant cell lines. We validated this mechanism using liquid chromatography–mass spectrometry (LC-MS) in MCF10A PIK3CA-isogenic breast epithelial cells and 4T1 PIK3CA-isogenic murine mammary cells treated with or without aspirin. Consistent with our model, aspirin markedly decreases arachidonic acid levels in PIK3CA-mutant cells, while exerting no detectable effect in wild-type MCF10A cells and only a modest reduction in wild-type 4T1 cells.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">The Institute of Cancer Research London</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Cell and Molecular Biology</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Signalling and Cancer Metabolism</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Poulogiannis</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">George</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">237 Fulham Road SW3 6JB LONDON</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">george.poulogiannis@icr.ac.uk</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">+442071535347</div>
</div>
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<label for="analysis_grid_item12" href="#AN007306" class="analysis__grid__item brightred">AN007306</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN007306</div>
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<label for="study_grid_item11" href="#ST004375" class="study__grid__item">ST004375: Dihydroorotate dehydrogenase (DHODH) promotes radioresistance in Lung Cancer - University of Oklahoma Health Sciences Center - Rajacharya, Girish</label>
<div class="grid__description" style="height:11em;max-height:11">
<div class="desc__grid">
<div class="desc__grid__item">STUDY_TITLE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Dihydroorotate dehydrogenase (DHODH) promotes radioresistance in Lung Cancer</div>
<div class="desc__grid__item">STUDY_TYPE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Translational Cancer Biology</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Our study shows that in a 393P syngeneic model of radioresistant lung cancer, the combination of RT and anti–PD-1 fails to suppress tumor growth, suggesting the limitations of this dual therapy in the context of radioresistance. Notably, only the triple combination of RT, anti–PD-1, and a DHODH inhibitor achieved the potent tumor suppressive effect, primarily through enhanced ferroptosis induction. It is worth noting that our preclinical studies employed a sequential treatment regimen—RT followed by anti–PD-1 administration—mirroring the approach used in the iSABR trial (66). These preclinical results suggest that radioresistant tumors may evade the cytotoxic effects of RT-immunotherapy combinations by upregulating ferroptosis defense mechanisms, such as DHODH, providing a mechanistic explanation for the inconsistent outcomes observed in clinical trials of RT combined with immune checkpoint blockade. Based on our studies, it will be useful to assess biomarkers (such as DHODH or p-CREB levels) that can predict patients’ responses to RT-immunotherapy combinations. Furthermore, given that leflunomide is already FDA-approved, our results provide a strong rationale for testing the combination of leflunomide, RT, and immunotherapy in patients with radioresistant lung cancer. In summary, our study reveals that DHODH serves as a redox-buffering enzyme that enables tumor cells to evade ferroptosis under radiation. This function is particularly relevant in the presence of IFN-γ, which enhances lipid peroxidation, and in tumors that have acquired resistance to radiation through metabolic reprogramming. Inhibiting DHODH disables a key antioxidant adaptation and exposes tumors to ferroptotic cell death, providing a mechanistically informed rationale for combining DHODH inhibitors with RT and immunotherapy.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">University of Oklahoma Health Sciences Center</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Oncology science</div>
<div class="desc__grid__item">LABORATORY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Dr singh lab</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Rajacharya</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Girish</div>
<div class="desc__grid__item">ADDRESS</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">940 Stanton L. Young Blvd., BMSB 340</div>
<div class="desc__grid__item">EMAIL</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">girishhalemirle-rajacharya@ou.edu</div>
<div class="desc__grid__item">PHONE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">4059685643</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">AN007310</div>
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<label for="study_grid_item12" href="#ST004387" class="study__grid__item">ST004387: Investigation of PPP-induced changes in the gut of honeybee workers using targeted metabolomics for SCFA determination. - Helmholtz Centre for Environmental Research - Uthoff, Cassandra</label>
<div class="grid__description" style="height:9em;max-height:9">
<div class="desc__grid">
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Investigation of PPP-induced changes in the gut of honeybee workers using targeted metabolomics for SCFA determination.</div>
<div class="desc__grid__item">STUDY_SUMMARY</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">To determine changes in the metabolic activity of the gut microbiota, we measured the concentrations of seven short-chain fatty acids (SCFA) and lactate. We found significant effects during both the exposure and post-exposure timepoints. Acetate levels were significantly decreased at exposure in comparison to the pre-exposure timepoint in all treatments. Moreover, propionate was significantly decreased after SIVANTO prime and Cantus exposure, while the control group showed an increase in comparison to the pre-exposure timepoint. We were also able to show significant changes in correlation analyses between bacterial abundances and SCFA concentrations, which can be associated to a functional change in the bacteria related to PPP exposure.</div>
<div class="desc__grid__item">INSTITUTE</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Helmholtz Centre for Environmental Research</div>
<div class="desc__grid__item">DEPARTMENT</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Molecular Toxicology</div>
<div class="desc__grid__item">LAST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Uthoff</div>
<div class="desc__grid__item">FIRST_NAME</div>
<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Cassandra</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">cassandra.uthoff@ufz.de</div>
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<label for="study_grid_item13" href="#ST004391" class="study__grid__item">ST004391: Metabolic changes in human cerebellum between Fragile X Syndrome (FXS) and Typically Developed (TD) patients. - UMass Chan Medical School - UMass Chan, Spinelli Lab</label>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Metabolic changes in human cerebellum between Fragile X Syndrome (FXS) and Typically Developed (TD) patients.</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Polar metabolites profiling in human FXS cerebellum compared to TD.</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">UMass Chan Medical School</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">Spinelli Lab</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">55 Lake Avenue North, Worcester, Massachusetts, 01605, USA</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">spinellilab@gmail.com</div>
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<div class="desc__grid__item" style="white-space:nowrap;overflow:hidden;text-overflow:ellipsis;width:calc(100%);">(508) 856-8989 ext. 68148</div>
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