diff --git a/configs/experiment/preprocessing/tile_masks_05mpp.yaml b/configs/experiment/preprocessing/tile_masks_05mpp.yaml
new file mode 100644
index 0000000..8cfc5a9
--- /dev/null
+++ b/configs/experiment/preprocessing/tile_masks_05mpp.yaml
@@ -0,0 +1,16 @@
+# @package _global_
+
+defaults:
+  - /data: dataset
+  - _self_
+
+slides_artifact_path: train_split/slides.parquet
+tiles_artifact_path: train_split/tiles.parquet
+tile_percentage_cols:
+  - tile_coverage_Nerve
+  - tile_coverage_Blood
+  - tile_coverage_Connective-Tissue
+  - tile_coverage_Fat
+  - tile_coverage_Epithelium
+  - tile_coverage_Muscle
+  - tile_coverage_Other
diff --git a/configs/preprocessing/tile_masks.yaml b/configs/preprocessing/tile_masks.yaml
new file mode 100644
index 0000000..a287440
--- /dev/null
+++ b/configs/preprocessing/tile_masks.yaml
@@ -0,0 +1,12 @@
+# @package _global_
+
+slides_artifact_path: ???
+tiles_artifact_path: ???
+tile_percentage_cols: ???
+
+max_concurrent: 1
+mlflow_artifact_path: tile_masks
+
+metadata:
+  run_name: Tile Masks ${dataset.name}
+  description: Tile mask generation
diff --git a/preprocessing/tile_masks.py b/preprocessing/tile_masks.py
new file mode 100644
index 0000000..9738f3d
--- /dev/null
+++ b/preprocessing/tile_masks.py
@@ -0,0 +1,107 @@
+from pathlib import Path
+from tempfile import TemporaryDirectory
+from typing import Any, cast
+
+import hydra
+import mlflow
+import pandas as pd
+import pyvips
+import torch
+from omegaconf import DictConfig
+from rationai.masks import tile_mask, write_big_tiff
+from rationai.masks.mask_builders import ScalarMaskBuilder
+from rationai.mlkit import autolog, with_cli_args
+from rationai.mlkit.lightning.loggers import MLFlowLogger
+from tqdm import tqdm
+
+
+def process_slide(
+    slide: dict[str, Any],
+    output_dir: str,
+    tile_percentage_cols: list[str],
+    tiles_path: str,
+) -> None:
+    slide_tiles = pd.read_parquet(
+        tiles_path,
+        columns=["x", "y", *tile_percentage_cols],
+        filters=[("slide_id", "==", slide["id"])],
+    )
+    filename = f"{Path(slide['path']).stem}.tiff"
+
+    for percentage_col in tile_percentage_cols:
+        builder = ScalarMaskBuilder(
+            save_dir=Path(output_dir, percentage_col),
+            filename=filename,
+            extent_x=slide["extent_x"],
+            extent_y=slide["extent_y"],
+            mpp_x=slide["mpp_x"],
+            mpp_y=slide["mpp_y"],
+            extent_tile=slide["tile_extent_x"],
+            stride=slide["stride_x"],
+        )
+        builder.update(
+            data=torch.tensor(slide_tiles[percentage_col].values).unsqueeze(1),
+            xs=torch.tensor(slide_tiles["x"].values),
+            ys=torch.tensor(slide_tiles["y"].values),
+        )
+        builder.save()
+
+    mask = tile_mask(
+        slide_tiles,
+        tile_extent=(slide["tile_extent_x"], slide["tile_extent_y"]),
+        size=(slide["extent_x"], slide["extent_y"]),
+    )
+    width, height = mask.size
+    mask_bytes = mask.tobytes()
+    del mask
+
+    write_big_tiff(
+        image=pyvips.Image.new_from_memory(
+            data=mask_bytes,
+            width=width,
+            height=height,
+            bands=1,
+            format="uchar",
+        ),
+        path=Path(output_dir, "outlines", filename),
+        mpp_x=slide["mpp_x"],
+        mpp_y=slide["mpp_y"],
+    )
+
+
+@with_cli_args(["+preprocessing=tile_masks"])
+@hydra.main(config_path="../configs", config_name="preprocessing", version_base=None)
+@autolog
+def main(config: DictConfig, logger: MLFlowLogger) -> None:
+    tiling_run_id = config.dataset.mlflow_artifacts.tiling_run_id
+    tile_percentage_cols: list[str] = list(config.tile_percentage_cols)
+
+    slides_path = mlflow.artifacts.download_artifacts(
+        run_id=tiling_run_id,
+        artifact_path=config.slides_artifact_path,
+    )
+    tiles_path = mlflow.artifacts.download_artifacts(
+        run_id=tiling_run_id,
+        artifact_path=config.tiles_artifact_path,
+    )
+    slides = pd.read_parquet(slides_path)
+
+    items = cast("list[dict[str, Any]]", slides.to_dict(orient="records"))
+
+    with TemporaryDirectory() as output_dir:
+        Path(output_dir, "outlines").mkdir()
+        for slide in tqdm(items):
+            process_slide(
+                slide,
+                output_dir=output_dir,
+                tile_percentage_cols=tile_percentage_cols,
+                tiles_path=tiles_path,
+            )
+
+        logger.log_artifacts(
+            local_dir=output_dir, artifact_path=config.mlflow_artifact_path
+        )
+
+
+if __name__ == "__main__":
+    main()
diff --git a/scripts/submit_tile_masks.py b/scripts/submit_tile_masks.py
new file mode 100644
index 0000000..7fc8a94
--- /dev/null
+++ b/scripts/submit_tile_masks.py
@@ -0,0 +1,18 @@
+from kube_jobs import storage, submit_job
+
+
+submit_job(
+    job_name="tissue-classification-tile-masks",
+    username=...,
+    cpu=8,
+    memory="64Gi",
+    gpu=None,
+    public=False,
+    script=[
+        "git clone https://github.com/RationAI/tissue-classification.git workdir",
+        "cd workdir",
+        "uv sync",
+        "uv run python -m preprocessing.tile_masks +experiment=...",
+    ],
+    storage=[storage.secure.DATA],
+)