diff --git a/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/persistent/PersistentTopic.java b/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/persistent/PersistentTopic.java
index a7c1714186974..069157b2dbe9d 100644
--- a/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/persistent/PersistentTopic.java
+++ b/pulsar-broker/src/main/java/org/apache/pulsar/broker/service/persistent/PersistentTopic.java
@@ -3039,6 +3039,10 @@ public void onUpdate(TopicPolicies policies) {
             replicators.forEach((name, replicator) -> replicator.getRateLimiter()
                     .ifPresent(DispatchRateLimiter::updateDispatchRate));
 
+            if (policies.getReplicationClusters() != null) {
+                checkReplicationAndRetryOnFailure();
+            }
+
             checkDeduplicationStatus();
 
             preCreateSubscriptionForCompactionIfNeeded();
diff --git a/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java b/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java
index 8811dce221aa3..c31373c05fcd6 100644
--- a/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java
+++ b/pulsar-broker/src/test/java/org/apache/pulsar/broker/service/ReplicatorTest.java
@@ -717,7 +717,7 @@ public void testReplicatorProducerClosing() throws Exception {
         assertNull(producer);
     }
 
-    @Test(priority = 5, timeOut = 30000)
+    @Test(priority = 4, timeOut = 30000)
     public void testReplicatorProducerName() throws Exception {
         log.info("--- Starting ReplicatorTest::testReplicatorProducerName ---");
         final String topicName = BrokerTestUtil.newUniqueName("persistent://pulsar/ns/testReplicatorProducerName");
@@ -739,7 +739,7 @@ public void testReplicatorProducerName() throws Exception {
         });
     }
 
-    @Test(priority = 5, timeOut = 30000)
+    @Test(priority = 4, timeOut = 30000)
     public void testReplicatorProducerNameWithUserDefinedReplicatorPrefix() throws Exception {
         log.info("--- Starting ReplicatorTest::testReplicatorProducerNameWithUserDefinedReplicatorPrefix ---");
         final String topicName = BrokerTestUtil.newUniqueName(
@@ -1427,4 +1427,32 @@ public void testReplicatorWithFailedAck() throws Exception {
 
     private static final Logger log = LoggerFactory.getLogger(ReplicatorTest.class);
 
+    @Test
+    public void testWhenUpdateReplicationCluster() throws Exception {
+        log.info("--- testWhenUpdateReplicationCluster ---");
+        String namespace = "pulsar/ns2";
+        admin1.namespaces().createNamespace(namespace);
+        admin1.namespaces().setNamespaceReplicationClusters(namespace, Sets.newHashSet("r1", "r2"));
+        final TopicName dest = TopicName.get(
+                BrokerTestUtil.newUniqueName("persistent://" + namespace + "/testWhenUpdateReplicationCluster"));
+        @Cleanup
+        MessageProducer producer1 = new MessageProducer(url1, dest);
+        log.info("--- Starting producer --- " + url1);
+
+        producer1.produce(2);
+
+        PersistentTopic topic = (PersistentTopic) pulsar1.getBrokerService().getTopic(dest.toString(), false)
+                .getNow(null).get();
+        Awaitility.await().untilAsserted(() -> {
+            assertTrue(topic.getReplicators().containsKey("r2"));
+        });
+
+        admin1.topics().setReplicationClusters(dest.toString(), Lists.newArrayList("r1"));
+
+        Awaitility.await().untilAsserted(() -> {
+            Set<String> replicationClusters = admin1.topics().getReplicationClusters(dest.toString(), false);
+            assertTrue(replicationClusters != null && replicationClusters.size() == 1);
+            assertTrue(topic.getReplicators().isEmpty());
+        });
+    }
 }