diff --git a/src/tir/analysis/block_access_region_detector.cc b/src/tir/analysis/block_access_region_detector.cc
index a15cecabddf9..d8fcee859f03 100644
--- a/src/tir/analysis/block_access_region_detector.cc
+++ b/src/tir/analysis/block_access_region_detector.cc
@@ -26,6 +26,8 @@
 #include <tvm/tir/op.h>
 #include <tvm/tir/stmt_functor.h>
 
+#include <unordered_map>
+
 #include "../transforms/ir_utils.h"
 namespace tvm {
 namespace tir {
@@ -78,6 +80,8 @@ class BlockReadWriteDetector : public StmtExprVisitor {
   Map<Var, Buffer> buffer_var_map_;
   /*! \brief The target buffer var mapping to its matching */
   std::unordered_map<const VarNode*, MatchBufferRegion> match_buffers_;
+  /*! \brief let bindings inside the block */
+  std::unordered_map<const VarNode*, PrimExpr> let_bindings_;
   /*!\ brief Internal analyzer. */
   arith::Analyzer ana_;
 
@@ -111,6 +115,7 @@ class BlockReadWriteDetector : public StmtExprVisitor {
   void VisitStmt_(const IfThenElseNode* op) override;
   void VisitStmt_(const BlockRealizeNode* op) override;
   void VisitStmt_(const BufferStoreNode* op) override;
+  void VisitStmt_(const LetStmtNode* op) override;
   void VisitExpr_(const BufferLoadNode* op) override;
   void VisitExpr_(const VarNode* op) override;
   void VisitExpr_(const CallNode* op) override;
@@ -149,7 +154,8 @@ void BlockReadWriteDetector::VisitExpr_(const VarNode* op) { UpdateOpaque(GetRef
 void BlockReadWriteDetector::VisitExpr_(const BufferLoadNode* op) {
   std::vector<arith::IntSet> relaxed_region;
   for (const PrimExpr& index : op->indices) {
-    relaxed_region.push_back(arith::EvalSet(arith::IntSet::Vector(index), dom_map_));
+    PrimExpr remapped_index = Substitute(index, let_bindings_);
+    relaxed_region.push_back(arith::EvalSet(arith::IntSet::Vector(remapped_index), dom_map_));
   }
   Update(&read_buffers_, &read_regions_, op->buffer, relaxed_region);
   ExprVisitor::VisitExpr_(op);
@@ -176,6 +182,12 @@ void BlockReadWriteDetector::VisitStmt_(const IfThenElseNode* op) {
   }
 }
 
+void BlockReadWriteDetector::VisitStmt_(const LetStmtNode* op) {
+  let_bindings_[op->var.get()] = op->value;
+  StmtVisitor::VisitStmt_(op);
+  let_bindings_.erase(op->var.get());
+}
+
 void BlockReadWriteDetector::VisitExpr_(const CallNode* op) {
   if (op->op.same_as(builtin::tvm_access_ptr())) {
     const VarNode* buffer_var = op->args[1].as<VarNode>();
@@ -225,7 +237,8 @@ void BlockReadWriteDetector::VisitExpr_(const CallNode* op) {
 void BlockReadWriteDetector::VisitStmt_(const BufferStoreNode* op) {
   std::vector<arith::IntSet> relaxed_region;
   for (const PrimExpr& index : op->indices) {
-    relaxed_region.push_back(arith::EvalSet(arith::IntSet::Vector(index), dom_map_));
+    PrimExpr remapped_index = Substitute(index, let_bindings_);
+    relaxed_region.push_back(arith::EvalSet(arith::IntSet::Vector(remapped_index), dom_map_));
   }
   Update(&writes_buffers_, &write_regions_, op->buffer, relaxed_region);
   StmtVisitor::VisitStmt_(op);
diff --git a/tests/python/tir-analysis/test_tir_analysis_get_block_access_region.py b/tests/python/tir-analysis/test_tir_analysis_get_block_access_region.py
index 21d832848e83..a65277df612d 100644
--- a/tests/python/tir-analysis/test_tir_analysis_get_block_access_region.py
+++ b/tests/python/tir-analysis/test_tir_analysis_get_block_access_region.py
@@ -15,10 +15,12 @@
 # specific language governing permissions and limitations
 # under the License.
 import pytest
+
 import tvm
+import tvm.testing
 from tvm import tir
-from tvm.script import tir as T
 from tvm.ir import Range
+from tvm.script import tir as T
 
 
 @T.prim_func
@@ -355,14 +357,33 @@ def test_access_of_decompose_reduction():
         tvm.ir.assert_structural_equal(block.writes, ret[1])
 
 
+def test_buffer_access_with_let_binding():
+    @T.prim_func
+    def func(
+        storage: T.Buffer((16, 16, 16), "float32"),
+        seq_slot_ids: T.Buffer((16,), "int32"),
+        history_slot_ids: T.Buffer((16,), "int32"),
+        output: T.Buffer((16, 16), "float32"),
+    ):
+        for i, s in T.grid(16, 16):
+            with T.block("copy"):
+                vi, vs = T.axis.remap("SS", [i, s])
+                T.reads(
+                    seq_slot_ids[vi],
+                    history_slot_ids[vi],
+                    storage[seq_slot_ids[vi], history_slot_ids[vi], vs],
+                )
+                T.writes(output[vi, vs])
+                seq_id: T.int32 = seq_slot_ids[vi]
+                history_id: T.int32 = history_slot_ids[vi]
+                output[vi, vs] = storage[seq_id, history_id, vs]
+
+    block = func.body.block.body.body.body.block
+    buffer_var_map = {buf.data: buf for buf in func.buffer_map.values()}
+    ret = tir.analysis.get_block_access_region(block, buffer_var_map)
+    tvm.ir.assert_structural_equal(block.reads, ret[0])
+    tvm.ir.assert_structural_equal(block.writes, ret[1])
+
+
 if __name__ == "__main__":
-    test_block_access_region_detector()
-    test_opaque_block()
-    test_opaque_access()
-    test_opaque_access_with_tvm_access_ptr()
-    test_match_buffer()
-    test_access_in_if_then_else_func()
-    test_access_in_branch_func()
-    test_access_of_padding_pattern()
-    test_access_of_reduction()
-    test_access_of_decompose_reduction()
+    tvm.testing.main()