diff --git a/src/tests/Loader/classloader/regressions/InvalidFriendAssemblyName/InvalidFriendAssemblyName.csproj b/src/tests/Loader/classloader/regressions/InvalidFriendAssemblyName/InvalidFriendAssemblyName.csproj
index 17cf9dbad70f50..33038b400ca760 100644
--- a/src/tests/Loader/classloader/regressions/InvalidFriendAssemblyName/InvalidFriendAssemblyName.csproj
+++ b/src/tests/Loader/classloader/regressions/InvalidFriendAssemblyName/InvalidFriendAssemblyName.csproj
@@ -1,4 +1,10 @@
 <Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <!-- This test relies on runtime compilation access checks to parse the invalid friend assembly name.
+         Crossgen2 does not implement these checks, and any checks would fail at build time, not run time. -->
+    <R2RIncompatible>true</R2RIncompatible>
+    <RequiresProcessIsolation>true</RequiresProcessIsolation>
+  </PropertyGroup>
   <ItemGroup>
     <Compile Include="InvalidFriendAssemblyName.cs" />
     <ProjectReference Include="$(TestLibraryProjectPath)" />