diff --git a/src/coreclr/clrdefinitions.cmake b/src/coreclr/clrdefinitions.cmake
index d22738910023c4..75a5fac08fbe2e 100644
--- a/src/coreclr/clrdefinitions.cmake
+++ b/src/coreclr/clrdefinitions.cmake
@@ -37,6 +37,10 @@ if (CLR_CMAKE_TARGET_UNIX)
 
 endif(CLR_CMAKE_TARGET_UNIX)
 
+if (CLR_CMAKE_TARGET_OSX AND CLR_CMAKE_TARGET_ARCH_ARM64)
+  add_compile_definitions($<$<NOT:$<BOOL:$<TARGET_PROPERTY:IGNORE_DEFAULT_TARGET_ARCH>>>:OSX_ARM64_ABI>)
+endif(CLR_CMAKE_TARGET_OSX AND CLR_CMAKE_TARGET_ARCH_ARM64)
+
 if(CLR_CMAKE_TARGET_ALPINE_LINUX)
   # Alpine Linux doesn't have fixed stack limit, this define disables some stack pointer
   # sanity checks in debug / checked build that rely on a fixed stack limit
@@ -234,7 +238,7 @@ function(set_target_definitions_to_custom_os_and_arch)
   set_target_properties(${TARGETDETAILS_TARGET} PROPERTIES IGNORE_DEFAULT_TARGET_ARCH TRUE)
   set_target_properties(${TARGETDETAILS_TARGET} PROPERTIES IGNORE_DEFAULT_TARGET_OS TRUE)
 
-  if ((TARGETDETAILS_OS STREQUAL "unix"))
+  if ((TARGETDETAILS_OS MATCHES "^unix"))
     target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE TARGET_UNIX)
     if (TARGETDETAILS_ARCH STREQUAL "x64")
       target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE UNIX_AMD64_ABI)
@@ -245,9 +249,12 @@ function(set_target_definitions_to_custom_os_and_arch)
       target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE UNIX_X86_ABI)
     elseif (TARGETDETAILS_ARCH STREQUAL "arm64")
     endif()
+    if ((TARGETDETAILS_ARCH STREQUAL "arm64") AND (TARGETDETAILS_OS STREQUAL "unix_osx"))
+      target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE OSX_ARM64_ABI)
+    endif()
   else()
     target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE TARGET_WINDOWS)
-  endif((TARGETDETAILS_OS STREQUAL "unix"))
+  endif((TARGETDETAILS_OS MATCHES "^unix"))
 
   if (TARGETDETAILS_ARCH STREQUAL "x86")
     target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE TARGET_X86)
@@ -262,7 +269,7 @@ function(set_target_definitions_to_custom_os_and_arch)
     target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE TARGET_ARM)
   endif()
 
-  if (NOT (TARGETDETAILS_ARCH STREQUAL "x86") OR (TARGETDETAILS_OS STREQUAL "unix"))
+  if (NOT (TARGETDETAILS_ARCH STREQUAL "x86") OR (TARGETDETAILS_OS MATCHES "^unix"))
     target_compile_definitions(${TARGETDETAILS_TARGET} PRIVATE FEATURE_EH_FUNCLETS)
-  endif (NOT (TARGETDETAILS_ARCH STREQUAL "x86") OR (TARGETDETAILS_OS STREQUAL "unix"))
+  endif (NOT (TARGETDETAILS_ARCH STREQUAL "x86") OR (TARGETDETAILS_OS MATCHES "^unix"))
 endfunction()
diff --git a/src/coreclr/src/jit/CMakeLists.txt b/src/coreclr/src/jit/CMakeLists.txt
index 914dc83bc5c7a7..a2776acc38ae51 100644
--- a/src/coreclr/src/jit/CMakeLists.txt
+++ b/src/coreclr/src/jit/CMakeLists.txt
@@ -17,7 +17,14 @@ function(create_standalone_jit)
   set(options)
   cmake_parse_arguments(TARGETDETAILS "${options}" "${oneValueArgs}" "${multiValueArgs}" ${ARGN})
 
-  set(JIT_ARCH_LINK_LIBRARIES gcinfo_${TARGETDETAILS_OS}_${TARGETDETAILS_ARCH})
+  if(TARGETDETAILS_OS STREQUAL "unix_osx")
+    if (NOT (TARGETDETAILS_ARCH STREQUAL "arm64"))
+      message(FATAL_ERROR "Only arm64 Apple has a special ABI, use just unix for x64 Mac OS." )
+    endif()
+    set(JIT_ARCH_LINK_LIBRARIES gcinfo_unix_arm64)
+  else()
+    set(JIT_ARCH_LINK_LIBRARIES gcinfo_${TARGETDETAILS_OS}_${TARGETDETAILS_ARCH})
+  endif()
 
   if(TARGETDETAILS_ARCH STREQUAL "x64")
     set(JIT_ARCH_SOURCES ${JIT_AMD64_SOURCES})
@@ -451,10 +458,12 @@ endif (FEATURE_MERGE_JIT_AND_ENGINE)
 # Creates a static library "clrjit_static" to link into the VM.
 add_subdirectory(static)
 
-if (CLR_CMAKE_TARGET_UNIX)
-set(TARGET_OS_NAME unix)
+if (CLR_CMAKE_TARGET_OSX AND CLR_CMAKE_TARGET_ARCH_ARM64)
+  set(TARGET_OS_NAME unix_osx) # Apple Arm64 has a special ABI, distinguish it.
+elseif (CLR_CMAKE_TARGET_UNIX)
+  set(TARGET_OS_NAME unix)
 else()
-set(TARGET_OS_NAME win)
+  set(TARGET_OS_NAME win)
 endif()
 
 create_standalone_jit(TARGET clrjit OS ${TARGET_OS_NAME} ARCH ${ARCH_TARGET_NAME} ADDITIONAL_DESTINATIONS sharedFramework)
@@ -472,6 +481,7 @@ endif ()
 if (CLR_CMAKE_BUILD_SUBSET_ALLJITS AND NOT CLR_CROSS_COMPONENTS_BUILD)
   if (CLR_CMAKE_TARGET_ARCH_ARM64 OR CLR_CMAKE_TARGET_ARCH_AMD64)
     create_standalone_jit(TARGET clrjit_unix_arm64_${ARCH_HOST_NAME} OS unix ARCH arm64)
+    create_standalone_jit(TARGET clrjit_unix_osx_arm64_${ARCH_HOST_NAME} OS unix_osx ARCH arm64)
     create_standalone_jit(TARGET clrjit_unix_x64_${ARCH_HOST_NAME} OS unix ARCH x64)
     create_standalone_jit(TARGET clrjit_win_arm64_${ARCH_HOST_NAME} OS win ARCH arm64)
     create_standalone_jit(TARGET clrjit_win_x64_${ARCH_HOST_NAME} OS win ARCH x64)
@@ -484,4 +494,4 @@ else()
   if (CLR_CMAKE_TARGET_UNIX)
     create_standalone_jit(TARGET clrjit_unix_${ARCH_TARGET_NAME}_${ARCH_HOST_NAME} OS unix ARCH ${ARCH_TARGET_NAME})
   endif(CLR_CMAKE_TARGET_UNIX)
-endif (CLR_CMAKE_BUILD_SUBSET_ALLJITS AND NOT CLR_CROSS_COMPONENTS_BUILD)
\ No newline at end of file
+endif (CLR_CMAKE_BUILD_SUBSET_ALLJITS AND NOT CLR_CROSS_COMPONENTS_BUILD)