diff --git a/eng/testing/tests.mobile.targets b/eng/testing/tests.mobile.targets
index 572213ee2c7830..d264a9aadc44b8 100644
--- a/eng/testing/tests.mobile.targets
+++ b/eng/testing/tests.mobile.targets
@@ -54,7 +54,7 @@
              AssemblyFile="$(RuntimeConfigParserTasksAssemblyPath)"
              Condition="'$(RuntimeConfigParserTasksAssemblyPath)' != ''" />
 
-  <Target Name="GenerateRuntimeConfig" Condition="'$(OutputType)' != 'library' and '$(TargetOS)' != 'Browser'">
+  <Target Name="GenerateRuntimeConfig" Condition="'$(TargetOS)' != 'Browser'">
     <PropertyGroup>
       <RuntimeConfigFilePath>$(PublishDir)$(AssemblyName).runtimeconfig.json</RuntimeConfigFilePath>
       <ParsedRuntimeConfigFilePath>$(PublishDir)runtimeconfig.bin</ParsedRuntimeConfigFilePath>
diff --git a/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs b/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
index d44f9bcfdd6614..9582b95ad4310d 100644
--- a/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
+++ b/src/libraries/Common/tests/TestUtilities/System/PlatformDetection.cs
@@ -97,7 +97,11 @@ public static bool IsDrawingSupported
 #if NETCOREAPP
                 if (!IsWindows)
                 {
-                    if (IsOSX)
+                    if (IsMobile)
+                    {
+                        return false;
+                    }
+                    else if (IsOSX)
                     {
                         return NativeLibrary.TryLoad("libgdiplus.dylib", out _);
                     }
diff --git a/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/ConsoleLifetimeExitTests.cs b/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/ConsoleLifetimeExitTests.cs
index ab803145a43873..5cc91dc9c33f63 100644
--- a/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/ConsoleLifetimeExitTests.cs
+++ b/src/libraries/Microsoft.Extensions.Hosting/tests/UnitTests/ConsoleLifetimeExitTests.cs
@@ -93,7 +93,8 @@ protected override async Task ExecuteAsync(CancellationToken stoppingToken)
         /// </summary>
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
         // SIGTERM is only handled on net6.0+, so the workaround to "clobber" the exit code is still in place on NetFramework
-        [SkipOnTargetFramework(TargetFrameworkMonikers.NetFramework)] 
+        [SkipOnTargetFramework(TargetFrameworkMonikers.NetFramework)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34582", TestPlatforms.Windows, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
         public void EnsureEnvironmentExitCode()
         {
             using var remoteHandle = RemoteExecutor.Invoke(async () =>
@@ -126,6 +127,7 @@ await Task.Run(() =>
         /// Tests that calling Environment.Exit from the "main" thread doesn't hang the process forever.
         /// </summary>
         [ConditionalFact(typeof(RemoteExecutor), nameof(RemoteExecutor.IsSupported))]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/34582", TestPlatforms.Windows, TargetFrameworkMonikers.Netcoreapp, TestRuntimes.Mono)]
         public void EnsureEnvironmentExitDoesntHang()
         {
             using var remoteHandle = RemoteExecutor.Invoke(async () =>
diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
index e4f52b617096a2..880da43a646539 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
@@ -171,29 +171,28 @@ public void TestExited_SynchronizingObject(bool invokeRequired)
         }
 
         [Fact]
-        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "Not supported on iOS, or tvOS.")]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void ProcessStart_TryExitCommandAsFileName_ThrowsWin32Exception()
         {
             Assert.Throws<Win32Exception>(() => Process.Start(new ProcessStartInfo { UseShellExecute = false, FileName = "exit", Arguments = "42" }));
         }
 
         [Fact]
-        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "Not supported on iOS, or tvOS.")]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void ProcessStart_UseShellExecuteFalse_FilenameIsUrl_ThrowsWin32Exception()
         {
             Assert.Throws<Win32Exception>(() => Process.Start(new ProcessStartInfo { UseShellExecute = false, FileName = "https://www.github.com/corefx" }));
         }
 
         [Fact]
-        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "Not supported on iOS, or tvOS.")]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void ProcessStart_TryOpenFolder_UseShellExecuteIsFalse_ThrowsWin32Exception()
         {
             Assert.Throws<Win32Exception>(() => Process.Start(new ProcessStartInfo { UseShellExecute = false, FileName = Path.GetTempPath() }));
         }
 
         [Fact]
-        [SkipOnPlatform(TestPlatforms.OSX, "OSX doesn't support throwing on Process.Start")]
-        [ActiveIssue("https://github.com/dotnet/runtime/issues/52882", TestPlatforms.MacCatalyst)]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void TestStartWithBadWorkingDirectory()
         {
             string program;
@@ -231,6 +230,7 @@ public void TestStartWithBadWorkingDirectory()
 
         [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.HasWindowsShell))]
         [OuterLoop("Launches File Explorer")]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void ProcessStart_UseShellExecute_OnWindows_OpenMissingFile_Throws()
         {
             string fileToOpen = Path.Combine(Environment.CurrentDirectory, "_no_such_file.TXT");
@@ -243,6 +243,7 @@ public void ProcessStart_UseShellExecute_OnWindows_OpenMissingFile_Throws()
         [InlineData(true)]
         [InlineData(false)]
         [OuterLoop("Launches File Explorer")]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void ProcessStart_UseShellExecute_OnWindows_DoesNotThrow(bool isFolder)
         {
             string fileToOpen;
@@ -500,7 +501,7 @@ public void HasExited_GetNotStarted_ThrowsInvalidOperationException()
         }
 
         [Fact]
-        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "Not supported on iOS, or tvOS.")]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS | TestPlatforms.MacCatalyst, "Not supported on iOS, tvOS, or MacCatalyst.")]
         public void Kill_NotStarted_ThrowsInvalidOperationException()
         {
             var process = new Process();
diff --git a/src/libraries/System.Drawing.Common/tests/System.Drawing.Common.Tests.csproj b/src/libraries/System.Drawing.Common/tests/System.Drawing.Common.Tests.csproj
index 1b9175f3eb5e12..ca1116cd5ad547 100644
--- a/src/libraries/System.Drawing.Common/tests/System.Drawing.Common.Tests.csproj
+++ b/src/libraries/System.Drawing.Common/tests/System.Drawing.Common.Tests.csproj
@@ -3,7 +3,7 @@
     <AllowUnsafeBlocks>true</AllowUnsafeBlocks>
     <IncludeRemoteExecutor>true</IncludeRemoteExecutor>
     <TargetFrameworks>$(NetCoreAppCurrent)-windows;$(NetCoreAppCurrent)-Unix;net48</TargetFrameworks>
-    <IgnoreForCI Condition="'$(TargetOS)' == 'Browser'">true</IgnoreForCI>
+    <IgnoreForCI Condition="'$(TargetsMobile)' == 'true'">true</IgnoreForCI>
   </PropertyGroup>
   <ItemGroup>
     <Compile Include="AssemblyInfo.cs" />
diff --git a/src/libraries/System.Runtime/tests/System/CharTests.cs b/src/libraries/System.Runtime/tests/System/CharTests.cs
index c495bc1ab6d18b..cd4de327b61519 100644
--- a/src/libraries/System.Runtime/tests/System/CharTests.cs
+++ b/src/libraries/System.Runtime/tests/System/CharTests.cs
@@ -1089,8 +1089,12 @@ public static IEnumerable<object[]> UpperLowerCasing_TestData()
 
             if (PlatformDetection.IsNotInvariantGlobalization)
             {
-                yield return new object[] { '\u0131', 'I', "tr-TR" };
-                yield return new object[] { 'i', '\u0130', "tr-TR" };
+                // Android has issues w/ tr-TR, see https://github.com/dotnet/runtime/issues/37069
+                if (!PlatformDetection.IsAndroid)
+                {
+                    yield return new object[] { '\u0131', 'I', "tr-TR" };
+                    yield return new object[] { 'i', '\u0130', "tr-TR" };
+                }
                 yield return new object[] { '\u0660', '\u0660', "en-US" };
             }
         }