diff --git a/src/coreclr/tools/aot/ILCompiler.ReadyToRun/Compiler/ReadyToRunCompilationModuleGroupBase.cs b/src/coreclr/tools/aot/ILCompiler.ReadyToRun/Compiler/ReadyToRunCompilationModuleGroupBase.cs
index 22a1efae2549d8..9b8ab3d6d6debc 100644
--- a/src/coreclr/tools/aot/ILCompiler.ReadyToRun/Compiler/ReadyToRunCompilationModuleGroupBase.cs
+++ b/src/coreclr/tools/aot/ILCompiler.ReadyToRun/Compiler/ReadyToRunCompilationModuleGroupBase.cs
@@ -123,7 +123,7 @@ public override ReadyToRunFlags GetReadyToRunFlags()
             {
                 flags |= ReadyToRunFlags.READYTORUN_FLAG_MultiModuleVersionBubble;
             }
-            if (CompileAllPossibleCrossModuleCode)
+            if (CompileAllPossibleCrossModuleCode || _compileGenericDependenciesFromVersionBubbleModuleSet)
             {
                 flags |= ReadyToRunFlags.READYTORUN_FLAG_UnrelatedR2RCode;
             }