diff --git a/eng/pipelines/common/templates/runtimes/run-test-job.yml b/eng/pipelines/common/templates/runtimes/run-test-job.yml
index da6d2bf83874c2..c8e3b9e90b59a0 100644
--- a/eng/pipelines/common/templates/runtimes/run-test-job.yml
+++ b/eng/pipelines/common/templates/runtimes/run-test-job.yml
@@ -212,7 +212,7 @@ jobs:
       # gc reliability may take up to 2 hours to shutdown. Some scenarios have very long iteration times.
       - name: timeoutPerTestInMinutes
         value: 240
-    - ${{ if in(parameters.testGroup, 'jitstress', 'jitstress-random', 'jitstress-isas-arm', 'jitstress-isas-x86', 'jitstressregs-x86', 'jitstressregs', 'jitstress2-jitstressregs', 'jitelthookenabled' ) }}:
+    - ${{ if in(parameters.testGroup, 'jitstress', 'jitstress-random', 'jitstress-isas-arm', 'jitstress-isas-x86', 'jitstress-isas-avx512', 'jitstressregs-x86', 'jitstressregs', 'jitstress2-jitstressregs', 'jitelthookenabled' ) }}:
       - name: timeoutPerTestCollectionInMinutes
         value: 120
       - name: timeoutPerTestInMinutes
@@ -268,7 +268,7 @@ jobs:
       timeoutInMinutes: 390
     ${{ if in(parameters.testGroup, 'gcstress-extra', 'r2r-extra', 'clrinterpreter', 'pgo', 'pgostress', 'jit-experimental') }}:
       timeoutInMinutes: 510
-    ${{ if eq(parameters.testGroup, 'jitstress-isas-x86') }}:
+    ${{ if in(parameters.testGroup, 'jitstress-isas-x86', 'jitstress-isas-avx512') }}:
       timeoutInMinutes: 960
 
     steps:
@@ -525,6 +525,9 @@ jobs:
           - jitstress_isas_2_x86_nosse41
           - jitstress_isas_2_x86_nosse42
           - jitstress_isas_2_x86_nossse3
+        ${{ if in(parameters.testGroup, 'jitstress-isas-avx512') }}:
+          scenarios:
+          - jitstress_isas_avx512_forceevex
         ${{ if in(parameters.testGroup, 'jitstressregs-x86') }}:
           scenarios:
           - jitstressregs1_x86_noavx
diff --git a/eng/pipelines/coreclr/jitstress-isas-avx512.yml b/eng/pipelines/coreclr/jitstress-isas-avx512.yml
new file mode 100644
index 00000000000000..55bc83e4d74a96
--- /dev/null
+++ b/eng/pipelines/coreclr/jitstress-isas-avx512.yml
@@ -0,0 +1,62 @@
+trigger:
+  batch: false
+  branches:
+    include:
+    - main
+  paths:
+    include:
+    - src/coreclr/jit/instrsxarch.h
+    - src/coreclr/jit/emitxarch.cpp
+    - src/coreclr/jit/emitxarch.h
+
+schedules:
+- cron: "30 19 * * 6"
+  displayName: Sat at 11:30 AM (UTC-8:00)
+  branches:
+    include:
+    - main
+  always: true
+
+extends:
+  template:  /eng/pipelines/common/templates/single-stage-pipeline-with-resources.yml
+  parameters:
+    jobs:
+
+    - template: /eng/pipelines/common/platform-matrix.yml
+      parameters:
+        jobTemplate: /eng/pipelines/common/build-coreclr-and-libraries-job.yml
+        buildConfig: checked
+        platforms:
+        # Current Linux and OSX x64 pipelines do not have machines which support AVX-512.
+        # - Linux_x64
+        # - OSX_x64
+        - windows_x64
+        - windows_x86
+        - CoreClrTestBuildHost # Either OSX_x64 or Linux_x64
+        jobParameters:
+          testGroup: jitstress-isas-avx512
+
+    - template: /eng/pipelines/common/platform-matrix.yml
+      parameters:
+        jobTemplate: /eng/pipelines/common/templates/runtimes/build-test-job.yml
+        buildConfig: checked
+        platforms:
+        - CoreClrTestBuildHost # Either OSX_x64 or Linux_x64
+        jobParameters:
+          testGroup: jitstress-isas-avx512
+
+    - template: /eng/pipelines/common/platform-matrix.yml
+      parameters:
+        jobTemplate: /eng/pipelines/common/templates/runtimes/run-test-job.yml
+        buildConfig: checked
+        platforms:
+        # Current Linux and OSX x64 pipelines do not have machines which support AVX-512.
+        # - Linux_x64
+        # - OSX_x64
+        - windows_x64
+        - windows_x86
+        helixQueueGroup: ci
+        helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
+        jobParameters:
+          testGroup: jitstress-isas-avx512
+          liveLibrariesBuildConfig: Release
diff --git a/src/coreclr/jit/compiler.h b/src/coreclr/jit/compiler.h
index 193399040296a3..347492cd630c0e 100644
--- a/src/coreclr/jit/compiler.h
+++ b/src/coreclr/jit/compiler.h
@@ -8999,6 +8999,14 @@ XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
     bool canUseEvexEncoding() const
     {
 #ifdef TARGET_XARCH
+
+#ifdef DEBUG
+        if (JitConfig.JitForceEVEXEncoding())
+        {
+            return true;
+        }
+#endif // DEBUG
+
         return compOpportunisticallyDependsOn(InstructionSet_AVX512F);
 #else
         return false;
@@ -9013,17 +9021,22 @@ XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
     //
     bool DoJitStressEvexEncoding() const
     {
-#ifdef TARGET_XARCH
-// Using JitStressEvexEncoding flag will force instructions which would
-// otherwise use VEX encoding but can be EVEX encoded to use EVEX encoding
-// This requires AVX512VL support.
-#ifdef DEBUG
+#if defined(TARGET_XARCH) && defined(DEBUG)
+        // Using JitStressEVEXEncoding flag will force instructions which would
+        // otherwise use VEX encoding but can be EVEX encoded to use EVEX encoding
+        // This requires AVX512VL support. JitForceEVEXEncoding forces this encoding, thus
+        // causing failure if not running on compatible hardware.
+
+        if (JitConfig.JitForceEVEXEncoding())
+        {
+            return true;
+        }
         if (JitConfig.JitStressEvexEncoding() && compOpportunisticallyDependsOn(InstructionSet_AVX512F_VL))
         {
             return true;
         }
-#endif // DEBUG
-#endif // TARGET_XARCH
+#endif // TARGET_XARCH && DEBUG
+
         return false;
     }
 
diff --git a/src/coreclr/jit/jitconfigvalues.h b/src/coreclr/jit/jitconfigvalues.h
index 2f337078a71de7..707c0cf7d09fb9 100644
--- a/src/coreclr/jit/jitconfigvalues.h
+++ b/src/coreclr/jit/jitconfigvalues.h
@@ -300,8 +300,10 @@ CONFIG_INTEGER(EnableEHWriteThru, W("EnableEHWriteThru"), 1) // Enable the regis
 CONFIG_INTEGER(EnableMultiRegLocals, W("EnableMultiRegLocals"), 1) // Enable the enregistration of locals that are
                                                                    // defined or used in a multireg context.
 #if defined(DEBUG)
-CONFIG_INTEGER(JitStressEvexEncoding, W("JitStressEvexEncoding"), 0) // Enable EVEX encoding for SIMD instructions.
-#endif // DEBUG                                                               // DEBUG
+CONFIG_INTEGER(JitStressEvexEncoding, W("JitStressEvexEncoding"), 0) // Enable EVEX encoding for SIMD instructions when
+                                                                     // AVX-512VL is available.
+CONFIG_INTEGER(JitForceEVEXEncoding, W("JitForceEVEXEncoding"), 0)   // Force EVEX encoding for SIMD instructions.
+#endif
 
 // clang-format off
 
diff --git a/src/tests/Common/testenvironment.proj b/src/tests/Common/testenvironment.proj
index 27e14c6c3194c9..b80b236966cf88 100644
--- a/src/tests/Common/testenvironment.proj
+++ b/src/tests/Common/testenvironment.proj
@@ -35,6 +35,7 @@
       DOTNET_EnableSSE41;
       DOTNET_EnableSSE42;
       DOTNET_EnableSSSE3;
+      DOTNET_JitForceEVEXEncoding;
       DOTNET_ForceRelocs;
       DOTNET_GCStress;
       DOTNET_GCName;
@@ -151,6 +152,7 @@
     <TestEnvironment Include="jitstress_isas_2_x86_nosse41" JitStress="2" EnableSSE41="0" /> <!-- Depends on SSSE3 and SSE3_4 -->
     <TestEnvironment Include="jitstress_isas_2_x86_nosse42" JitStress="2" EnableSSE42="0" /> <!-- Depends on SSE41 -->
     <TestEnvironment Include="jitstress_isas_2_x86_nossse3" JitStress="2" EnableSSSE3="0" /> <!-- Depends on SSE3 -->
+    <TestEnvironment Include="jitstress_isas_avx512_forceevex" JitForceEVEXEncoding="1" /> <!-- Depends on AVX512 -->
     <TestEnvironment Include="jitstressregs1_x86_noavx" JitStressRegs="1" EnableAVX="0" />
     <TestEnvironment Include="jitstressregs2_x86_noavx" JitStressRegs="2" EnableAVX="0" />
     <TestEnvironment Include="jitstressregs3_x86_noavx" JitStressRegs="3" EnableAVX="0" />