diff --git a/src/tests/GC/Regressions/Github/Runtime_76219/Runtime_76219.csproj b/src/tests/GC/Regressions/Github/Runtime_76219/Runtime_76219.csproj
index 1ddf97612fbc5b..aeec2e9d6b4cd7 100644
--- a/src/tests/GC/Regressions/Github/Runtime_76219/Runtime_76219.csproj
+++ b/src/tests/GC/Regressions/Github/Runtime_76219/Runtime_76219.csproj
@@ -2,6 +2,8 @@
   <PropertyGroup>
     <OutputType>Exe</OutputType>
     <Optimize>True</Optimize>
+    <!-- Move it out of CI for 78899 -->
+    <CLRTestPriority>1</CLRTestPriority>
 
     <!-- This test needs GCStress mode but it doesn't take long to execute
          so is fine to keep it in the inner loop -->
diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 6424d170a89d68..ce41bf518cb9d0 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -60,6 +60,9 @@
         <ExcludeList Include="$(XunitTestBinBase)/Interop/MonoAPI/**">
             <Issue>CoreCLR does not implement the mono embedding API</Issue>
         </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/GC/Regressions/Github/Runtime_76219/Runtime_76219/*">
+            <Issue>https://github.com/dotnet/runtime/issues/78899</Issue>
+        </ExcludeList>
     </ItemGroup>
 
     <!-- All Unix targets on all runtimes -->