diff --git a/src/browser/ReactEventTopLevelCallback.js b/src/browser/ReactEventTopLevelCallback.js
index 5d202ccb3a5..821bf24d491 100644
--- a/src/browser/ReactEventTopLevelCallback.js
+++ b/src/browser/ReactEventTopLevelCallback.js
@@ -19,11 +19,13 @@
 
 "use strict";
 
+var PooledClass = require('PooledClass');
 var ReactEventEmitter = require('ReactEventEmitter');
 var ReactInstanceHandles = require('ReactInstanceHandles');
 var ReactMount = require('ReactMount');
 
 var getEventTarget = require('getEventTarget');
+var mixInto = require('mixInto');
 
 /**
  * @type {boolean}
@@ -49,6 +51,53 @@ function findParent(node) {
   return parent;
 }
 
+/**
+ * Calls ReactEventEmitter.handleTopLevel for each node stored in bookKeeping's
+ * ancestor list. Separated from createTopLevelCallback to avoid try/finally
+ * deoptimization.
+ *
+ * @param {string} topLevelType
+ * @param {DOMEvent} nativeEvent
+ * @param {TopLevelCallbackBookKeeping} bookKeeping
+ */
+function handleTopLevelImpl(topLevelType, nativeEvent, bookKeeping) {
+  var topLevelTarget = ReactMount.getFirstReactDOM(
+    getEventTarget(nativeEvent)
+  ) || window;
+
+  // Loop through the hierarchy, in case there's any nested components.
+  // It's important that we build the array of ancestors before calling any
+  // event handlers, because event handlers can modify the DOM, leading to
+  // inconsistencies with ReactMount's node cache. See #1105.
+  var ancestor = topLevelTarget;
+  while (ancestor) {
+    bookKeeping.ancestors.push(ancestor);
+    ancestor = findParent(ancestor);
+  }
+
+  for (var i = 0, l = bookKeeping.ancestors.length; i < l; i++) {
+    topLevelTarget = bookKeeping.ancestors[i];
+    var topLevelTargetID = ReactMount.getID(topLevelTarget) || '';
+    ReactEventEmitter.handleTopLevel(
+      topLevelType,
+      topLevelTarget,
+      topLevelTargetID,
+      nativeEvent
+    );
+  }
+}
+
+// Used to store ancestor hierarchy in top level callback
+function TopLevelCallbackBookKeeping() {
+  this.ancestors = [];
+}
+mixInto(TopLevelCallbackBookKeeping, {
+  destructor: function() {
+    this.ancestors.length = 0;
+  }
+});
+PooledClass.addPoolingTo(TopLevelCallbackBookKeeping);
+
 /**
  * Top-level callback creator used to implement event handling using delegation.
  * This is used via dependency injection.
@@ -85,21 +134,12 @@ var ReactEventTopLevelCallback = {
       if (!_topLevelListenersEnabled) {
         return;
       }
-      var topLevelTarget = ReactMount.getFirstReactDOM(
-        getEventTarget(nativeEvent)
-      ) || window;
-
-      // Loop through the hierarchy, in case there's any nested components.
-      while (topLevelTarget) {
-        var topLevelTargetID = ReactMount.getID(topLevelTarget) || '';
-        ReactEventEmitter.handleTopLevel(
-          topLevelType,
-          topLevelTarget,
-          topLevelTargetID,
-          nativeEvent
-        );
-
-        topLevelTarget = findParent(topLevelTarget);
+
+      var bookKeeping = TopLevelCallbackBookKeeping.getPooled();
+      try {
+        handleTopLevelImpl(topLevelType, nativeEvent, bookKeeping);
+      } finally {
+        TopLevelCallbackBookKeeping.release(bookKeeping);
       }
     };
   }
diff --git a/src/browser/__tests__/ReactEventTopLevelCallback-test.js b/src/browser/__tests__/ReactEventTopLevelCallback-test.js
index 6782d006c2b..6b7dc0cde0f 100644
--- a/src/browser/__tests__/ReactEventTopLevelCallback-test.js
+++ b/src/browser/__tests__/ReactEventTopLevelCallback-test.js
@@ -84,6 +84,39 @@ describe('ReactEventTopLevelCallback', function() {
       expect(calls[2][EVENT_TARGET_PARAM])
         .toBe(grandParentControl.getDOMNode());
     });
+
+    it('should not get confused by disappearing elements', function() {
+      var childContainer = document.createElement('div');
+      var childControl = <div>Child</div>;
+      var parentContainer = document.createElement('div');
+      var parentControl = <div>Parent</div>;
+      ReactMount.renderComponent(childControl, childContainer);
+      ReactMount.renderComponent(parentControl, parentContainer);
+      parentControl.getDOMNode().appendChild(childContainer);
+
+      // ReactEventEmitter.handleTopLevel might remove the target from the DOM.
+      // Here, we have handleTopLevel remove the node when the first event
+      // handlers are called; we'll still expect to receive a second call for
+      // the parent control.
+      var childNode = childControl.getDOMNode();
+      ReactEventEmitter.handleTopLevel.mockImplementation(
+        function(topLevelType, topLevelTarget, topLevelTargetID, nativeEvent) {
+          if (topLevelTarget === childNode) {
+            ReactMount.unmountComponentAtNode(childContainer);
+          }
+        }
+      );
+
+      var callback = ReactEventTopLevelCallback.createTopLevelCallback('test');
+      callback({
+        target: childNode
+      });
+
+      var calls = ReactEventEmitter.handleTopLevel.mock.calls;
+      expect(calls.length).toBe(2);
+      expect(calls[0][EVENT_TARGET_PARAM]).toBe(childNode);
+      expect(calls[1][EVENT_TARGET_PARAM]).toBe(parentControl.getDOMNode());
+    });
   });
 
   it('should not fire duplicate events for a React DOM tree', function() {