diff --git a/google/cloud/spanner_dbapi/connection.py b/google/cloud/spanner_dbapi/connection.py
index 91b63a2da1..9fa2269eae 100644
--- a/google/cloud/spanner_dbapi/connection.py
+++ b/google/cloud/spanner_dbapi/connection.py
@@ -20,6 +20,7 @@
 from google.api_core.exceptions import Aborted
 from google.api_core.gapic_v1.client_info import ClientInfo
 from google.cloud import spanner_v1 as spanner
+from google.cloud.spanner_v1 import RequestOptions
 from google.cloud.spanner_v1.session import _get_retry_delay
 from google.cloud.spanner_v1.snapshot import Snapshot
 
@@ -103,6 +104,7 @@ def __init__(self, instance, database, read_only=False):
         self._own_pool = True
         self._read_only = read_only
         self._staleness = None
+        self.request_priority = None
 
     @property
     def autocommit(self):
@@ -442,11 +444,18 @@ def run_statement(self, statement, retried=False):
                 ResultsChecksum() if retried else statement.checksum,
             )
 
+        if self.request_priority is not None:
+            req_opts = RequestOptions(priority=self.request_priority)
+            self.request_priority = None
+        else:
+            req_opts = None
+
         return (
             transaction.execute_sql(
                 statement.sql,
                 statement.params,
                 param_types=statement.param_types,
+                request_options=req_opts,
             ),
             ResultsChecksum() if retried else statement.checksum,
         )
diff --git a/tests/unit/spanner_dbapi/test_connection.py b/tests/unit/spanner_dbapi/test_connection.py
index e15f6af33b..23fc098afc 100644
--- a/tests/unit/spanner_dbapi/test_connection.py
+++ b/tests/unit/spanner_dbapi/test_connection.py
@@ -883,6 +883,42 @@ def test_staleness_single_use_readonly_autocommit(self):
 
         connection.database.snapshot.assert_called_with(read_timestamp=timestamp)
 
+    def test_request_priority(self):
+        from google.cloud.spanner_dbapi.checksum import ResultsChecksum
+        from google.cloud.spanner_dbapi.cursor import Statement
+        from google.cloud.spanner_v1 import RequestOptions
+
+        sql = "SELECT 1"
+        params = []
+        param_types = {}
+        priority = 2
+
+        connection = self._make_connection()
+        connection._transaction = mock.Mock(committed=False, rolled_back=False)
+        connection._transaction.execute_sql = mock.Mock()
+
+        connection.request_priority = priority
+
+        req_opts = RequestOptions(priority=priority)
+
+        connection.run_statement(
+            Statement(sql, params, param_types, ResultsChecksum(), False)
+        )
+
+        connection._transaction.execute_sql.assert_called_with(
+            sql, params, param_types=param_types, request_options=req_opts
+        )
+        assert connection.request_priority is None
+
+        # check that priority is applied for only one request
+        connection.run_statement(
+            Statement(sql, params, param_types, ResultsChecksum(), False)
+        )
+
+        connection._transaction.execute_sql.assert_called_with(
+            sql, params, param_types=param_types, request_options=None
+        )
+
 
 def exit_ctx_func(self, exc_type, exc_value, traceback):
     """Context __exit__ method mock."""