diff --git a/CHANGELOG.md b/CHANGELOG.md
index e09b232b92..749815260f 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -4,6 +4,12 @@
 
 [1]: https://pypi.org/project/google-cloud-spanner/#history
 
+## [3.22.2](https://github.com/googleapis/python-spanner/compare/v3.22.1...v3.22.2) (2022-10-10)
+
+### Bug Fixes
+
+* **deps:** Allow protobuf 3.19.5 ([#839](https://github.com/googleapis/python-spanner/issues/839)) ([06725fc](https://github.com/googleapis/python-spanner/commit/06725fcf7fb216ad0cffb2cb568f8da38243c32e))
+
 ## [3.22.1](https://github.com/googleapis/python-spanner/compare/v3.22.0...v3.22.1) (2022-10-04)
 
 
diff --git a/setup.py b/setup.py
index b14776ee2d..9cc4b48572 100644
--- a/setup.py
+++ b/setup.py
@@ -22,7 +22,7 @@
 
 name = "google-cloud-spanner"
 description = "Cloud Spanner API client library"
-version = "3.22.1"
+version = "3.22.2"
 # Should be one of:
 # 'Development Status :: 3 - Alpha'
 # 'Development Status :: 4 - Beta'
@@ -35,7 +35,7 @@
     "proto-plus >= 1.22.0, <2.0.0dev",
     "sqlparse >= 0.3.0",
     "packaging >= 14.3",
-    "protobuf >= 3.20.2, <5.0.0dev",
+    "protobuf>=3.19.5,<5.0.0dev,!=3.20.0,!=3.20.1,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
 ]
 extras = {
     "tracing": [
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index 7391e756d0..5a63b04a4d 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -15,4 +15,4 @@ opentelemetry-api==1.1.0
 opentelemetry-sdk==1.1.0
 opentelemetry-instrumentation==0.20b0
 packaging==14.3
-protobuf==3.20.2
+protobuf==3.19.5