diff --git a/app/worker/devMenu.js b/app/worker/devMenu.js
index caa5f357..71955ccb 100644
--- a/app/worker/devMenu.js
+++ b/app/worker/devMenu.js
@@ -1,16 +1,13 @@
 /* eslint-disable no-underscore-dangle */
 
-import { avoidWarnForRequire } from './utils';
 import { toggleNetworkInspect } from './networkInspect';
 
 let availableDevMenuMethods = {};
 
-export const checkAvailableDevMenuMethods = async (enableNetworkInspect = false) => {
-  const done = await avoidWarnForRequire('NativeModules', 'AsyncStorage');
-  const NativeModules = window.__DEV__ ? window.require('NativeModules') : {};
-  const AsyncStorage = window.__DEV__ ? window.require('AsyncStorage') : {};
-  done();
-
+export const checkAvailableDevMenuMethods = async (
+  { NativeModules, AsyncStorage },
+  enableNetworkInspect = false
+) => {
   // RN 0.43 use DevSettings, DevMenu will be deprecated
   const DevSettings = NativeModules.DevSettings || NativeModules.DevMenu;
   // Currently `show dev menu` is only on DevMenu
@@ -23,7 +20,7 @@ export const checkAvailableDevMenuMethods = async (enableNetworkInspect = false)
     ...DevSettings,
     show: showDevMenu,
     networkInspect: toggleNetworkInspect,
-    clearAsyncStorage: () => AsyncStorage.clear().catch(f => f),
+    clearAsyncStorage: AsyncStorage.clear ? () => AsyncStorage.clear().catch(f => f) : undefined,
   };
   const result = Object.keys(methods).filter(key => !!methods[key]);
   availableDevMenuMethods = methods;
diff --git a/app/worker/index.js b/app/worker/index.js
index cd8b12e2..ae713ae1 100644
--- a/app/worker/index.js
+++ b/app/worker/index.js
@@ -15,6 +15,7 @@ import { checkAvailableDevMenuMethods, invokeDevMenuMethod } from './devMenu';
 import { reportDefaultReactDevToolsPort } from './reactDevTools';
 import devToolsEnhancer, { composeWithDevTools } from './reduxAPI';
 import * as RemoteDev from './remotedev';
+import { getRequiredModules, ignoreRNDIntervalSpy } from './utils';
 
 /* eslint-disable no-underscore-dangle */
 self.__REMOTEDEV__ = RemoteDev;
@@ -34,14 +35,15 @@ const setupRNDebuggerBeforeImportScript = message => {
   self.__REACT_DEVTOOLS_PORT__ = message.reactDevToolsPort;
 };
 
-const setupRNDebugger = message => {
+const setupRNDebugger = async message => {
   // We need to regularly update JS runtime
   // because the changes of worker message (Redux DevTools, DevMenu)
   // doesn't notify to the remote JS runtime
   self.__RND_INTERVAL__ = setInterval(function() {}, 100); // eslint-disable-line
-
-  checkAvailableDevMenuMethods(message.networkInspect);
-  reportDefaultReactDevToolsPort();
+  const modules = await getRequiredModules();
+  ignoreRNDIntervalSpy(modules);
+  checkAvailableDevMenuMethods(modules, message.networkInspect);
+  reportDefaultReactDevToolsPort(modules);
 };
 
 const messageHandlers = {
diff --git a/app/worker/reactDevTools.js b/app/worker/reactDevTools.js
index d57b680e..43bb7762 100644
--- a/app/worker/reactDevTools.js
+++ b/app/worker/reactDevTools.js
@@ -1,7 +1,5 @@
 /* eslint-disable no-underscore-dangle */
 
-import { avoidWarnForRequire } from './utils';
-
 const methodGlobalName = '__REPORT_REACT_DEVTOOLS_PORT__';
 
 const reportReactDevToolsPort = (port, platform) =>
@@ -10,11 +8,8 @@ const reportReactDevToolsPort = (port, platform) =>
     platform,
   });
 
-export const reportDefaultReactDevToolsPort = async () => {
-  const done = await avoidWarnForRequire('setupDevtools', 'Platform');
-  const setupDevtools = window.__DEV__ ? window.require('setupDevtools') : undefined;
-  const Platform = window.__DEV__ ? window.require('Platform') : {};
-  done();
+export const reportDefaultReactDevToolsPort = async ({ setupDevtools, Platform }) => {
+  if (Platform.__empty) return;
   /*
    * [Fallback] React Native version under 0.39 can't specified the port
    */
diff --git a/app/worker/utils.js b/app/worker/utils.js
index b3c668d7..27a4a5fe 100644
--- a/app/worker/utils.js
+++ b/app/worker/utils.js
@@ -1,5 +1,7 @@
+/* eslint-disable no-underscore-dangle */
+
 // Avoid warning of use `window.require` on dev mode
-export const avoidWarnForRequire = (...moduleNames) => {
+const avoidWarnForRequire = moduleNames => {
   if (!moduleNames.length) moduleNames.push('NativeModules');
   return new Promise(resolve =>
     setTimeout(() => {
@@ -20,3 +22,60 @@ export const avoidWarnForRequire = (...moduleNames) => {
     })
   );
 };
+
+const requiredModules = [
+  'MessageQueue',
+  'NativeModules',
+  'AsyncStorage',
+  'Platform',
+  'setupDevtools',
+];
+export const getRequiredModules = async () => {
+  const done = await avoidWarnForRequire(requiredModules);
+  const modules = {};
+  requiredModules.forEach(
+    name => (modules[name] = window.__DEV__ ? window.require(name) : { __empty: true })
+  );
+  done();
+  return modules;
+};
+
+const TO_JS = 0;
+const isRNDInterval = info =>
+  info.type === TO_JS &&
+  info.module === 'JSTimersExecution' &&
+  info.method === 'callTimers' &&
+  info.args &&
+  info.args[0] &&
+  info.args[0][0] === self.__RND_INTERVAL__;
+
+export const ignoreRNDIntervalSpy = async ({ MessageQueue }) => {
+  if (MessageQueue.__empty) return;
+  // Wrap spy function if it already set
+  if (MessageQueue.prototype.__spy) {
+    const originalSpyFn = MessageQueue.prototype.__spy;
+    MessageQueue.prototype.__spy = info => {
+      if (isRNDInterval(info)) return;
+      return originalSpyFn(info);
+    };
+  }
+  MessageQueue.spy = spyOrToggle => {
+    if (spyOrToggle === true) {
+      MessageQueue.prototype.__spy = info => {
+        if (isRNDInterval(info)) return;
+        console.log(
+          `${info.type === TO_JS ? 'N->JS' : 'JS->N'} : ` +
+            `${info.module ? `${info.module}.` : ''}${info.method}` +
+            `(${JSON.stringify(info.args)})`
+        );
+      };
+    } else if (spyOrToggle === false) {
+      MessageQueue.prototype.__spy = null;
+    } else {
+      MessageQueue.prototype.__spy = info => {
+        if (isRNDInterval(info)) return;
+        return spyOrToggle(info);
+      };
+    }
+  };
+};
diff --git a/test/e2e/fixture/setup.js b/test/e2e/fixture/setup.js
index 25e86463..162953b5 100644
--- a/test/e2e/fixture/setup.js
+++ b/test/e2e/fixture/setup.js
@@ -10,6 +10,10 @@ const requiredModules = {
   Platform: {},
   setupDevtools: undefined,
   AsyncStorage: {},
+  MessageQueue: {
+    spy: () => {},
+    prototype: { __spy: null },
+  },
 };
 // Simulate React Native's window.require polyfill
 window.require = moduleName => {