diff --git a/packages/neuron-ui/src/components/DataSetting/hooks.ts b/packages/neuron-ui/src/components/DataSetting/hooks.ts
index 44a07d733f..6f7b461a81 100644
--- a/packages/neuron-ui/src/components/DataSetting/hooks.ts
+++ b/packages/neuron-ui/src/components/DataSetting/hooks.ts
@@ -17,6 +17,8 @@ export const useDataPath = (
   type: Parameters<typeof stopProcessMonitor>[0]
 ) => {
   const [t] = useTranslation()
+  const [isSaving, setIsSaveing] = useState(false)
+  const [savingType, setSavingType] = useState<string | null>()
   const [prevPath, setPrevPath] = useState<string>()
   const [currentPath, setCurrentPath] = useState<string | undefined>()
   const { dialogRef, openDialog, closeDialog } = useDialogWrapper()
@@ -49,14 +51,28 @@ export const useDataPath = (
       }
     })
   }, [closeDialog, type])
-  const onConfirm = useCallback(() => {
-    setPath(currentPath!).then(res => {
-      if (isSuccessResponse(res)) {
-        setPrevPath(currentPath)
-        closeDialog()
-      }
-    })
-  }, [currentPath, closeDialog, setPrevPath, setPath])
+  const onConfirm = useCallback(
+    e => {
+      const { dataset } = e.currentTarget
+      setIsSaveing(true)
+      setSavingType(dataset.syncType)
+      setPath({
+        dataPath: currentPath!,
+        clearCache: type === 'ckb' && dataset?.resync === 'true',
+      })
+        .then(res => {
+          if (isSuccessResponse(res)) {
+            setPrevPath(currentPath)
+            closeDialog()
+          }
+        })
+        .finally(() => {
+          setIsSaveing(false)
+          setSavingType(null)
+        })
+    },
+    [currentPath, closeDialog, setPrevPath, setPath]
+  )
   return {
     prevPath,
     currentPath,
@@ -64,6 +80,8 @@ export const useDataPath = (
     dialogRef,
     onCancel,
     onConfirm,
+    isSaving,
+    savingType,
   }
 }
 
diff --git a/packages/neuron-ui/src/components/DataSetting/index.module.scss b/packages/neuron-ui/src/components/DataSetting/index.module.scss
index 63ebb162b1..dcfd558df8 100644
--- a/packages/neuron-ui/src/components/DataSetting/index.module.scss
+++ b/packages/neuron-ui/src/components/DataSetting/index.module.scss
@@ -9,6 +9,7 @@
 
   .name {
     font-weight: bold;
+    display: flex;
   }
 
   .content {
@@ -63,4 +64,29 @@
   & > svg {
     flex-shrink: 0;
   }
-}
\ No newline at end of file
+}
+
+.infoIconContainer {
+  position: relative;
+  display: inline-flex;
+  align-items: center;
+  padding-left: 4px;
+  z-index: 11;
+
+  &::after {
+    display: none;
+    position: absolute;
+    left: -20px;
+    top: 120%;
+    content: attr(data-tip);
+    padding: 4px 12px;
+    border-radius: 6px;
+    background: #cccccc;
+    font-weight: 300;
+    width: 400px;
+  }
+
+  &:hover::after {
+    display: block;
+  }
+}
diff --git a/packages/neuron-ui/src/components/DataSetting/index.tsx b/packages/neuron-ui/src/components/DataSetting/index.tsx
index eaf994a914..aec1541534 100644
--- a/packages/neuron-ui/src/components/DataSetting/index.tsx
+++ b/packages/neuron-ui/src/components/DataSetting/index.tsx
@@ -6,8 +6,9 @@ import { useDispatch } from 'states'
 import { getCkbNodeDataPath, getIndexerDataPath, setCkbNodeDataPath, setIndexerDataPath } from 'services/remote'
 import { ReactComponent as Attention } from 'widgets/Icons/ExperimentalAttention.svg'
 import CopyZone from 'widgets/CopyZone'
-import { OpenFolder } from 'widgets/Icons/icon'
+import { OpenFolder, InfoCircleOutlined } from 'widgets/Icons/icon'
 import { shell } from 'electron'
+import Spinner from 'widgets/Spinner'
 import { useDataPath } from './hooks'
 
 import styles from './index.module.scss'
@@ -41,7 +42,7 @@ const itemProps: Record<
 const SetItem = ({ type }: { type: keyof typeof itemProps }) => {
   const props = itemProps[type]
   const [t] = useTranslation()
-  const { onSetting, prevPath, currentPath, dialogRef, onCancel, onConfirm } = useDataPath(
+  const { onSetting, prevPath, currentPath, dialogRef, onCancel, onConfirm, isSaving, savingType } = useDataPath(
     props.getPath,
     props.setPath,
     props.type
@@ -53,7 +54,15 @@ const SetItem = ({ type }: { type: keyof typeof itemProps }) => {
   }, [prevPath])
   return (
     <>
-      <div className={styles.name}>{t(`settings.data.${props.titleI18nKey}`)}:</div>
+      <div className={styles.name}>
+        {t(`settings.data.${props.titleI18nKey}`)}
+        {type === 'ckbNode' ? (
+          <span className={styles.infoIconContainer} data-tip={t('settings.data.disabled-set-path')}>
+            <InfoCircleOutlined />
+          </span>
+        ) : null}
+        :
+      </div>
       <div className={styles.path}>
         <CopyZone content={prevPath || ''} className={styles.content}>
           {prevPath}
@@ -65,12 +74,47 @@ const SetItem = ({ type }: { type: keyof typeof itemProps }) => {
         <div className={styles.describe}>{t(`settings.data.${props.tipI18nKey}`, { prevPath, currentPath })}</div>
         <div className={styles.attention}>
           <Attention />
-          {t('settings.data.resync-describe')}
+          {type === 'ckbNode'
+            ? t('settings.data.resync-ckb-node-describe')
+            : t('settings.data.resync-indexer-describe')}
         </div>
         <div className={styles.action}>
-          <Button label={t('settings.data.cancel')} type="cancel" onClick={onCancel} />
-          <Button label={t('settings.data.move-data-finish')} type="primary" onClick={onConfirm} />
-          <Button label={t('settings.data.re-sync')} type="primary" onClick={onConfirm} />
+          <Button disabled={isSaving} label={t('settings.data.cancel')} type="cancel" onClick={onCancel} />
+          <Button
+            disabled={isSaving}
+            data-sync-type="move"
+            label={t('settings.data.move-data-finish')}
+            type="primary"
+            onClick={onConfirm}
+          >
+            {isSaving && savingType === 'move' ? (
+              <Spinner
+                label={t('settings.data.move-data-finish')}
+                labelPosition="right"
+                styles={{ root: { marginRight: 5 }, label: { color: '#FFF' } }}
+              />
+            ) : (
+              (t('settings.data.move-data-finish') as string)
+            )}
+          </Button>
+          <Button
+            disabled={isSaving}
+            data-sync-type="resync"
+            data-resync="true"
+            label={t('settings.data.re-sync')}
+            type="primary"
+            onClick={onConfirm}
+          >
+            {isSaving && savingType === 'resync' ? (
+              <Spinner
+                label={t('settings.data.re-sync')}
+                labelPosition="right"
+                styles={{ root: { marginRight: 5 }, label: { color: '#FFF' } }}
+              />
+            ) : (
+              (t('settings.data.re-sync') as string)
+            )}
+          </Button>
         </div>
       </dialog>
     </>
diff --git a/packages/neuron-ui/src/locales/en.json b/packages/neuron-ui/src/locales/en.json
index f368780878..216627233f 100644
--- a/packages/neuron-ui/src/locales/en.json
+++ b/packages/neuron-ui/src/locales/en.json
@@ -372,7 +372,7 @@
         }
       },
       "data": {
-        "ckb-node-data": "CKB Node Data",
+        "ckb-node-data": "CKB Node Config & Storage",
         "ckb-indexer-data": "CKB Indexer Data",
         "set": "Set",
         "cache": "Cache",
@@ -382,10 +382,12 @@
         "clearing-cache": "Clearing...",
         "remove-ckb-data-tip": "Please move CKB Node Data from {{prevPath}} to {{currentPath}} and then click on \"Data have been moved\" to start from the previously synchronized block; Or click on \"Synchronize from scratch\" to start with synchronizing from scratch.",
         "remove-indexer-data-tip": "Please move Indexer Data from {{prevPath}} to {{currentPath}} and then click on \"Data have been moved\" to start from the previously synchronized block; Or click on \"Synchronize from scratch\" to start with synchronizing from scratch.",
-        "resync-describe": "Attention: Synchronize from scratch won't remove previously downloaded CKB Node(or Indexer) Data.",
+        "resync-ckb-node-describe": "Attention: Synchronizing from scratch won't remove previously downloaded CKB Node Data, but it will remove downloaded Indexer Data",
+        "resync-indexer-describe": "Attention: Synchronizing from scratch won't remove previously downloaded Indexer Data.",
         "cancel": "Cancel",
         "move-data-finish": "Data have been moved",
-        "re-sync": "Synchronize from scratch"
+        "re-sync": "Synchronize from scratch",
+        "disabled-set-path": "When the CKB node is started manually, the CKB Node Config and Storage path configuration doesn't take effect"
       }
     },
     "password-request": {
diff --git a/packages/neuron-ui/src/locales/zh-tw.json b/packages/neuron-ui/src/locales/zh-tw.json
index 86bd7072c0..1efcb3f965 100644
--- a/packages/neuron-ui/src/locales/zh-tw.json
+++ b/packages/neuron-ui/src/locales/zh-tw.json
@@ -365,7 +365,7 @@
         }
       },
       "data": {
-        "ckb-node-data": "節點數據",
+        "ckb-node-data": "節點配置和數據",
         "ckb-indexer-data": "Indexer 數據",
         "set": "設置",
         "cache": "緩存",
@@ -376,9 +376,11 @@
         "remove-ckb-data-tip": "請將 CKB Node 數據從 {{prevPath}} 移動至 {{currentPath}}然後點擊 \"數據轉移完成\" 開始從已知區塊同步; 否則點擊 \"重新同步\" 開始重新同步.",
         "remove-indexer-data-tip": "請將 Indexer 數據從 {{prevPath}} 移動至 {{currentPath}}然後點擊 \"數據轉移完成\" 開始從已知區塊同步; 否則點擊 \"重新同步\" 開始重新同步.",
         "cancel": "取消",
-        "resync-describe": "註意: 重新同步不會刪除當前已同步的 CKB Node(Indexer) 數據.",
+        "resync-ckb-node-describe": "註意: 重新同步不會刪除當前已同步的 CKB Node 數據，但會刪除已同步的 Indexer 數據。",
+        "resync-indexer-describe": "註意: 重新同步不會刪除當前已同步的 Indexer 數據.",
         "move-data-finish": "數據轉移完成",
-        "re-sync": "重新同步"
+        "re-sync": "重新同步",
+        "disabled-set-path": "手動啟動 CKB 節點時，設置 CKB Node 節點配置和路徑無法生效"
       }
     },
     "password-request": {
diff --git a/packages/neuron-ui/src/locales/zh.json b/packages/neuron-ui/src/locales/zh.json
index 186a8c1406..ccd351d180 100644
--- a/packages/neuron-ui/src/locales/zh.json
+++ b/packages/neuron-ui/src/locales/zh.json
@@ -365,7 +365,7 @@
         }
       },
       "data": {
-        "ckb-node-data": "节点数据",
+        "ckb-node-data": "节点配置和数据",
         "ckb-indexer-data": "Indexer 数据",
         "set": "设置",
         "cache": "缓存",
@@ -375,10 +375,12 @@
         "clearing-cache": "清空中...",
         "remove-ckb-data-tip": "请将 CKB Node 数据从 {{prevPath}} 移动至 {{currentPath}}然后点击 \"数据转移完成\" 开始从已知区块同步; 否则点击 \"重新同步\" 开始重新同步.",
         "remove-indexer-data-tip": "请将 Indexer 数据从 {{prevPath}} 移动至 {{currentPath}}然后点击 \"数据转移完成\" 开始从已知区块同步; 否则点击 \"重新同步\" 开始重新同步.",
-        "resync-describe": "注意: 重新同步不会删除当前已同步的 CKB Node(Indexer) 数据.",
+        "resync-ckb-node-describe": "注意: 重新同步不会删除当前已同步的 CKB Node 数据，但会删除已同步的 Indexer 数据。",
+        "resync-indexer-describe": "注意: 重新同步不会删除当前已同步的 Indexer 数据.",
         "cancel": "取消",
         "move-data-finish": "数据转移完成",
-        "re-sync": "重新同步"
+        "re-sync": "重新同步",
+        "disabled-set-path": "手动启动 CKB 节点时，设置 CKB Node 节点配置和路径无法生效"
       }
     },
     "password-request": {
diff --git a/packages/neuron-ui/src/services/remote/app.ts b/packages/neuron-ui/src/services/remote/app.ts
index 76340290cd..20fe5a0c06 100644
--- a/packages/neuron-ui/src/services/remote/app.ts
+++ b/packages/neuron-ui/src/services/remote/app.ts
@@ -18,9 +18,11 @@ export const handleViewError = remoteApi<string>('handle-view-error')
 export const showSettings = remoteApi<Controller.ShowSettingsParams>('show-settings')
 export const setLocale = remoteApi<typeof LOCALES[number]>('set-locale')
 export const getCkbNodeDataPath = remoteApi<void, string>('get-ckb-node-data-path')
-export const setCkbNodeDataPath = remoteApi<string, string>('set-ckb-node-data-path')
+export const setCkbNodeDataPath = remoteApi<{ dataPath: string; clearCache?: boolean }, string>(
+  'set-ckb-node-data-path'
+)
 export const getIndexerDataPath = remoteApi<void, string>('get-indexer-data-path')
-export const setIndexerDataPath = remoteApi<string, string>('set-indexer-data-path')
+export const setIndexerDataPath = remoteApi<{ dataPath: string }, string>('set-indexer-data-path')
 export const stopProcessMonitor = remoteApi<'ckb' | 'ckb-indexer'>('stop-process-monitor')
 export const startProcessMonitor = remoteApi<'ckb' | 'ckb-indexer'>('start-process-monitor')
 
diff --git a/packages/neuron-wallet/src/controllers/api.ts b/packages/neuron-wallet/src/controllers/api.ts
index 2488d9a9e7..33d77cf380 100644
--- a/packages/neuron-wallet/src/controllers/api.ts
+++ b/packages/neuron-wallet/src/controllers/api.ts
@@ -13,6 +13,8 @@ import {
   BrowserWindow
 } from 'electron'
 import { t } from 'i18next'
+import path from 'path'
+import fs from 'fs'
 import env from 'env'
 import { showWindow } from './app/show-window'
 import CommonUtils from 'utils/common'
@@ -462,9 +464,27 @@ export default class ApiController {
       }
     })
 
-    handle('set-ckb-node-data-path', (_, dataPath: string) => {
+    handle('set-ckb-node-data-path', async (_, { dataPath, clearCache }: { dataPath: string; clearCache: boolean }) => {
+      let finallyClearCache = clearCache
+      if (!finallyClearCache && !fs.existsSync(path.join(dataPath, 'ckb.toml'))) {
+        const { response } = await dialog.showMessageBox(BrowserWindow.getFocusedWindow()!, {
+          type: 'info',
+          message: t('messages.no-exist-ckb-node-data', { path: dataPath }),
+          buttons: [t('common.ok'), t('common.cancel')]
+        })
+        if (response === 1) {
+          return {
+            status: ResponseCode.Fail,
+          }
+        } else {
+          finallyClearCache = true
+        }
+      }
       SettingsService.getInstance().ckbDataPath = dataPath
-      stopMonitor('ckb-indexer')
+      await stopMonitor('ckb-indexer')
+      if (finallyClearCache) {
+        await IndexerService.clearCache(true)
+      }
       startMonitor(undefined, true)
       return {
         status: ResponseCode.Success,
@@ -479,7 +499,7 @@ export default class ApiController {
       }
     })
 
-    handle('set-indexer-data-path', (_, dataPath: string) => {
+    handle('set-indexer-data-path', (_, { dataPath }: { dataPath: string }) => {
       SettingsService.getInstance().indexerDataPath = dataPath
       startMonitor('ckb-indexer', true)
       return {
diff --git a/packages/neuron-wallet/src/locales/en.ts b/packages/neuron-wallet/src/locales/en.ts
index 482fe0dc5a..2a1b83aff3 100644
--- a/packages/neuron-wallet/src/locales/en.ts
+++ b/packages/neuron-wallet/src/locales/en.ts
@@ -133,7 +133,8 @@ export default {
       'multisig-lock-hash-mismatch': 'The current multisig address does not match the transaction to be approved',
       'sudt-acp-have-data': 'The destroying sUDT acp account have amount',
       'no-match-address-for-sign': 'Not found matched address',
-      'target-lock-error': 'CKB asset account can only transfer to sepe256k1 or acp address'
+      'target-lock-error': 'CKB asset account can only transfer to sepe256k1 or acp address',
+      'no-exist-ckb-node-data': '{{path}} has no CKB Node config and storage, press ok to synchronize from scratch'
     },
     messageBox: {
       button: {
diff --git a/packages/neuron-wallet/src/locales/zh-tw.ts b/packages/neuron-wallet/src/locales/zh-tw.ts
index a55529586c..41e531a3b1 100644
--- a/packages/neuron-wallet/src/locales/zh-tw.ts
+++ b/packages/neuron-wallet/src/locales/zh-tw.ts
@@ -123,7 +123,8 @@ export default {
       'multisig-not-signed': '多簽交易缺少部分簽名',
       'sudt-acp-have-data': '待銷毀的 sUDT 賬戶資產不為 0',
       'no-match-address-for-sign': '没有找到匹配的地址',
-      'target-lock-error': 'CKB 資產只能轉賬到 secp256k1 或者 acp 地址'
+      'target-lock-error': 'CKB 資產只能轉賬到 secp256k1 或者 acp 地址',
+      'no-exist-ckb-node-data': '{{path}} 目錄下沒有找到 CKB Node 配置和數據, 點擊繼續重新同步'
     },
     messageBox: {
       button: {
diff --git a/packages/neuron-wallet/src/locales/zh.ts b/packages/neuron-wallet/src/locales/zh.ts
index 86a2a59832..158abe7ec2 100644
--- a/packages/neuron-wallet/src/locales/zh.ts
+++ b/packages/neuron-wallet/src/locales/zh.ts
@@ -124,7 +124,8 @@ export default {
       'multisig-not-signed': '多签交易缺少部分签名',
       'sudt-acp-have-data': '待销毁的 sUDT 账户资产不为 0',
       'no-match-address-for-sign': '没有找到匹配的地址',
-      'target-lock-error': 'CKB 资产只能转账到 secp256k1 或者 acp 地址'
+      'target-lock-error': 'CKB 资产只能转账到 secp256k1 或者 acp 地址',
+      'no-exist-ckb-node-data': '{{path}} 目录下没有找到 CKB Node 配置和数据, 点击继续重新同步'
     },
     messageBox: {
       button: {