diff --git a/CHANGES.md b/CHANGES.md
index 8428c733..c3e5bff5 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -15,6 +15,11 @@ development source code and as such may not be routinely kept up to date.
 
 ## Improvements
 
+* `nextstrain setup <pathogen>` and `nextstrain version --pathogens` now list
+  the available workflows for a pathogen if the pathogen lists the workflows
+  in the it's top-level `nextstrain-pathogen.yaml` file.
+  ([#461](https://github.com/nextstrain/cli/pull/461))
+
 * Snakemake's storage support downloaded files (stored in `.snakemake/storage/`)
   are now downloaded from AWS Batch builds by default.
 
diff --git a/doc/changes.md b/doc/changes.md
index 15044d75..d7341315 100644
--- a/doc/changes.md
+++ b/doc/changes.md
@@ -19,6 +19,11 @@ development source code and as such may not be routinely kept up to date.
 (v-next-improvements)=
 ### Improvements
 
+* `nextstrain setup <pathogen>` and `nextstrain version --pathogens` now list
+  the available workflows for a pathogen if the pathogen lists the workflows
+  in the it's top-level `nextstrain-pathogen.yaml` file.
+  ([#461](https://github.com/nextstrain/cli/pull/461))
+
 * Snakemake's storage support downloaded files (stored in `.snakemake/storage/`)
   are now downloaded from AWS Batch builds by default.
 
diff --git a/doc/commands/run.rst b/doc/commands/run.rst
index b920391c..a36b176b 100644
--- a/doc/commands/run.rst
+++ b/doc/commands/run.rst
@@ -60,8 +60,11 @@ positional arguments
     Available workflows may vary per pathogen (and possibly between
     pathogen version).  Some pathogens may provide multiple variants or
     base configurations of a top-level workflow, e.g. as in
-    ``phylogenetic/mpxv`` and ``phylogenetic/hmpxv1``.  Refer to the
-    pathogen's own documentation for valid workflow names.
+    ``phylogenetic/mpxv`` and ``phylogenetic/hmpxv1``.
+    Run ``nextstrain version --pathogens`` to see a list of registered
+    workflows per pathogen version. If the pathogen does not have
+    registered workflows, then refer to the pathogen's own documentation
+    for valid workflow names.
 
     Workflow names conventionally correspond directly to directory
     paths in the pathogen source, but this may not always be the case.
diff --git a/nextstrain/cli/command/run.py b/nextstrain/cli/command/run.py
index 5340841f..d278fb95 100644
--- a/nextstrain/cli/command/run.py
+++ b/nextstrain/cli/command/run.py
@@ -67,8 +67,11 @@ def register_parser(subparser):
             Available workflows may vary per pathogen (and possibly between
             pathogen version).  Some pathogens may provide multiple variants or
             base configurations of a top-level workflow, e.g. as in
-            ``phylogenetic/mpxv`` and ``phylogenetic/hmpxv1``.  Refer to the
-            pathogen's own documentation for valid workflow names.
+            ``phylogenetic/mpxv`` and ``phylogenetic/hmpxv1``.
+            Run ``nextstrain version --pathogens`` to see a list of registered
+            workflows per pathogen version. If the pathogen does not have
+            registered workflows, then refer to the pathogen's own documentation
+            for valid workflow names.
 
             Workflow names conventionally correspond directly to directory
             paths in the pathogen source, but this may not always be the case.
@@ -225,6 +228,9 @@ def run(opts):
     # Resolve pathogen and workflow names to a local workflow directory.
     pathogen = PathogenVersion(opts.pathogen)
 
+    if opts.workflow not in pathogen.registered_workflows():
+        print(f"The {opts.workflow!r} workflow is not registered as a compatible workflow, but trying to run anyways.")
+
     workflow_directory = pathogen.workflow_path(opts.workflow)
 
     if not workflow_directory.is_dir() or not (workflow_directory / "Snakefile").is_file():
diff --git a/nextstrain/cli/command/version.py b/nextstrain/cli/command/version.py
index 498c5a35..4ab8a925 100644
--- a/nextstrain/cli/command/version.py
+++ b/nextstrain/cli/command/version.py
@@ -71,5 +71,12 @@ def run(opts):
                     print("    " + str(version) + (f"={version.url or ''}" if opts.verbose else ""), "(default)" if is_default else "")
                     if opts.verbose:
                         print("      " + str(version.path))
+
+                    if registered_workflows := version.registered_workflows():
+                        print("      " + "Available workflows:")
+                        for workflow in registered_workflows:
+                            print("        " + workflow)
+                    else:
+                        print("      " + "No workflows listed, please refer to pathogen docs.")
         else:
             print("  (none)")
diff --git a/nextstrain/cli/pathogens.py b/nextstrain/cli/pathogens.py
index 60c533fe..7afbdc49 100644
--- a/nextstrain/cli/pathogens.py
+++ b/nextstrain/cli/pathogens.py
@@ -130,6 +130,7 @@ class PathogenVersion:
 
     setup_receipt: Optional[dict] = None
     url: Optional[URL] = None
+    registration: Optional[dict] = None
 
 
     def __init__(self, name_version_url: str, new_setup: bool = False):
@@ -243,6 +244,9 @@ def __init__(self, name_version_url: str, new_setup: bool = False):
         self.registration_path  = self.path / "nextstrain-pathogen.yaml"
         self.setup_receipt_path = self.path.with_suffix(self.path.suffix + ".json")
 
+        if self.registration_path.exists():
+            self.registration = read_pathogen_registration(self.registration_path)
+
         if not new_setup:
             if not self.path.is_dir():
                 # XXX TODO: This error case should maybe be handled outside of
@@ -301,6 +305,23 @@ def __init__(self, name_version_url: str, new_setup: bool = False):
         self.url = url
 
 
+    def registered_workflows(self) -> Dict[str, Dict]:
+        """
+        Parses :attr:`.registration` to return a dict of registered
+        compatible workflows, where the keys are workflow names.
+        """
+        if self.registration is None:
+            debug("pathogen does not have a registration")
+            return {}
+
+        workflows = self.registration.get("compatibility", {}).get("nextstrain run")
+        if not isinstance(workflows, dict):
+            debug(f"pathogen registration.compatibility['nextstrain runs'] is not a dict (got a {type(workflows).__name__})")
+            return {}
+
+        return workflows
+
+
     def workflow_path(self, workflow: str) -> Path:
         return self.path / workflow
 
@@ -448,6 +469,8 @@ def setup(self, dry_run: bool = False, force: bool = False) -> SetupStatus:
             json.dump(self.setup_receipt, f, indent = "  ")
             print(file = f)
 
+        self.registration = read_pathogen_registration(self.registration_path)
+
         return True
 
 
@@ -455,20 +478,22 @@ def test_setup(self) -> SetupTestResults:
         def test_compatibility() -> SetupTestResult:
             msg = "nextstrain-pathogen.yaml declares `nextstrain run` compatibility"
 
-            try:
-                registration = read_pathogen_registration(self.registration_path)
-            except (OSError, yaml.YAMLError, ValueError):
-                if DEBUGGING:
-                    traceback.print_exc()
+            if self.registration is None:
                 return msg + "\n(couldn't read registration)", False
 
             try:
-                compatibility = registration["compatibility"]["nextstrain run"]
+                compatibility = self.registration["compatibility"]["nextstrain run"]
             except (KeyError, IndexError, TypeError):
                 if DEBUGGING:
                     traceback.print_exc()
                 return msg + "\n(couldn't find 'compatibility: nextstrain run: …' field)", False
 
+            if compatibility:
+                if workflows := self.registered_workflows():
+                    msg += f"\nAvailable workflows: {list(workflows.keys())}"
+                else:
+                    msg += f"\nNo workflows listed, please refer to pathogen docs."
+
             return msg, bool(compatibility)
 
         return [
@@ -841,21 +866,28 @@ def sorted_versions(vs: Iterable[str]) -> List[str]:
     return [v.original for v in [*reversed(compliant), *non_compliant]]
 
 
-def read_pathogen_registration(path: Path) -> Dict:
+def read_pathogen_registration(path: Path) -> Optional[Dict]:
     """
     Reads a ``nextstrain-pathogen.yaml`` file at *path* and returns a dict of
     its deserialized contents.
-    """
-    with path.open("r", encoding = "utf-8") as f:
-        registration = yaml.safe_load(f)
 
-    # XXX TODO SOON: Consider doing actual schema validation here in the
-    # future.
-    #   -trs, 12 Dec 2024
-    if not isinstance(registration, dict):
-        raise ValueError(f"pathogen registration not a dict (got a {type(registration).__name__}): {str(path)!r}")
-
-    return registration
+    Returns ``None`` if there was an issue reading the registration.
+    """
+    try:
+        with path.open("r", encoding = "utf-8") as f:
+            registration = yaml.safe_load(f)
+
+        # XXX TODO SOON: Consider doing actual schema validation here in the
+        # future.
+        #   -trs, 12 Dec 2024
+        if not isinstance(registration, dict):
+            raise ValueError(f"pathogen registration not a dict (got a {type(registration).__name__}): {str(path)!r}")
+
+        return registration
+    except (OSError, yaml.YAMLError, ValueError):
+        if DEBUGGING:
+            traceback.print_exc()
+        return None
 
 
 # We query a nextstrain.org API instead of querying GitHub's API directly for a