diff --git a/nodejs/README.md b/nodejs/README.md
index 6430c88c11..8966ff6ed8 100644
--- a/nodejs/README.md
+++ b/nodejs/README.md
@@ -38,6 +38,7 @@ Following instrumentations from the metapackage are included:
 - `net` *- default*
 - `pg` *- default*
 - `pino`
+- `prisma`
 - `redis` *- default*
 - `restify`
 - `socket.io`
diff --git a/nodejs/package-lock.json b/nodejs/package-lock.json
index bcefa34c0e..54f5ef9ea7 100644
--- a/nodejs/package-lock.json
+++ b/nodejs/package-lock.json
@@ -1871,6 +1871,18 @@
         "url": "https://opencollective.com/pkgr"
       }
     },
+    "node_modules/@prisma/instrumentation": {
+      "version": "6.19.3",
+      "resolved": "https://registry.npmjs.org/@prisma/instrumentation/-/instrumentation-6.19.3.tgz",
+      "integrity": "sha512-gwU1D4pxrtBZXINZwSseEal+h8OghvIVZIH3VRv6+vPFAkZk1ykFUVcOhhboBc5WmhoD42NTJjla2i7GFNcZWA==",
+      "license": "Apache-2.0",
+      "dependencies": {
+        "@opentelemetry/instrumentation": ">=0.52.0 <1"
+      },
+      "peerDependencies": {
+        "@opentelemetry/api": "^1.8"
+      }
+    },
     "node_modules/@sinonjs/commons": {
       "version": "3.0.1",
       "resolved": "https://registry.npmjs.org/@sinonjs/commons/-/commons-3.0.1.tgz",
@@ -8749,7 +8761,8 @@
         "@opentelemetry/resources": "^2.0.0",
         "@opentelemetry/sdk-logs": "^0.218.0",
         "@opentelemetry/sdk-metrics": "^2.0.0",
-        "@opentelemetry/sdk-trace-node": "^2.0.0"
+        "@opentelemetry/sdk-trace-node": "^2.0.0",
+        "@prisma/instrumentation": "^6.19.3"
       },
       "devDependencies": {
         "@types/mocha": "^10.0.9",
diff --git a/nodejs/packages/layer/package.json b/nodejs/packages/layer/package.json
index 5fa8383233..c56bf718d1 100644
--- a/nodejs/packages/layer/package.json
+++ b/nodejs/packages/layer/package.json
@@ -81,7 +81,8 @@
     "@opentelemetry/resources": "^2.0.0",
     "@opentelemetry/sdk-logs": "^0.218.0",
     "@opentelemetry/sdk-metrics": "^2.0.0",
-    "@opentelemetry/sdk-trace-node": "^2.0.0"
+    "@opentelemetry/sdk-trace-node": "^2.0.0",
+    "@prisma/instrumentation": "^6.19.3"
   },
   "devDependencies": {
     "@types/mocha": "^10.0.9",
diff --git a/nodejs/packages/layer/src/wrapper.ts b/nodejs/packages/layer/src/wrapper.ts
index 3cb46403bd..f27b649843 100644
--- a/nodejs/packages/layer/src/wrapper.ts
+++ b/nodejs/packages/layer/src/wrapper.ts
@@ -236,6 +236,10 @@ async function defaultConfigureInstrumentations() {
       await import('@opentelemetry/instrumentation-pino');
     instrumentations.push(new PinoInstrumentation());
   }
+  if (activeInstrumentations.has('prisma')) {
+    const { PrismaInstrumentation } = await import('@prisma/instrumentation');
+    instrumentations.push(new PrismaInstrumentation());
+  }
   if (activeInstrumentations.has('redis')) {
     const { RedisInstrumentation } =
       await import('@opentelemetry/instrumentation-redis');